Por favor, use este identificador para citar o enlazar este ítem: http://hdl.handle.net/10201/19061

Título: Chemopreventive effects of NSAlDs against colorectal cancer, regulation of apoptosis and mitosis by COX-1 and COX-2
Fecha de publicación: 1998
Editorial: Murcia : F. Hernández
ISSN: 0213-3911
Materias relacionadas: CDU::6 - Ciencias aplicadas::61 - Medicina
Palabras clave: Cyclooxygenase enzymes
Apoptosis
Resumen: There is a wealth of evidence that nonsteroidal anti-inflammatory drugs (NSAIDs) can prevent colorectal cancer. In this article the role of cyclooxygenase 1 and 2, the principle target of NSAIDs, in the development of colorectal cancer is reviewed. Cyclooxygenase is constituitevely expressed in normal colonic epithelium and surrounding stroma and could catalyse the generation of malondialdehyde which is a known mutagen and could initiate colorectal carcinogenesis. Mutation of APC which is an early genetic event leads to the expression of cyclooxygenase 2 which may prevents the appropriate apoptosis of mutant adenoma cells. Other proneoplastic effects of cyclooxygenase include changing the action of Transforming Growth Factor l3 from anti-proliferative to proproliferative, reducing adherence to extracellular matrix, promotes metastasis and angiogenesis. These properties of cyclooxygenases suggest that inhibition of both isoforms may have important protective effects against colorectal cancer.
Autor/es principal/es: Watson, A.J.M.
Publicado en: Histology and histopathology
URI: http://hdl.handle.net/10201/19061
Tipo de documento: info:eu-repo/semantics/article
Número páginas / Extensión: 7
Derechos: info:eu-repo/semantics/openAccess
Aparece en las colecciones:Vol.13, nº 2 (1998)



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