Por favor, use este identificador para citar o enlazar este ítem: http://hdl.handle.net/10201/19051

Título: The effects of chronic administration of captopril on the mouse median eminence
Fecha de publicación: 1998
Editorial: Murcia : F. Hernández
ISSN: 0213-3911
Materias relacionadas: CDU::6 - Ciencias aplicadas::61 - Medicina
Palabras clave: Captopril
Vasopressin
Resumen: The effects of Captopril (an angiotensinconverting enzyme inhibitor) on the median eminence (ME) of the male albino mouse have been examined using morphometric and immunohistochemical procedures. We measured the nuclear area of the ependymocytes of the ME and of the glial cells of the reticular external zone of the ME. We also determined the cell/neuropil coefficient (CNC), which expreses the relation between cellular area and neuropil of the ME, and the global volume of the ME in each animal. For the immunohistochemical study we used rabbit antiarginine- vasopressin, and compared the results in the different groups of mice. We detected an increase in the immunoreactive material (arginine-vasopressin, A-V) and an increase in the global volume of the organ and also an increase of the neuropil of the ME after the longest exposure to the drug. These alterations could be related to the inhibition of the brain angiotensin 11 by captopril and the accumulation of vasopressin in the fibrous tract that runs from the paraventricular nucleus (PVN) to the neurohypophysis.
Autor/es principal/es: Castañeyra Perdomo, A.
Carmona-Calero, E.
Pérez-Delgado, M. del M.
Pérez-González, H.
Marrero-Gordillo, N.
Ferres Torres, R.
Publicado en: Histology and histopathology
URI: http://hdl.handle.net/10201/19051
Tipo de documento: info:eu-repo/semantics/article
Número páginas / Extensión: 5
Derechos: info:eu-repo/semantics/openAccess
Aparece en las colecciones:Vol.13, nº 2 (1998)

Ficheros en este ítem:
Fichero Descripción TamañoFormato 
The effects of chronic administration of captopril on the mouse median eminence.pdf313,98 kBAdobe PDFVista previa
Visualizar/Abrir


Los ítems de Digitum están protegidos por copyright, con todos los derechos reservados, a menos que se indique lo contrario.