Por favor, use este identificador para citar o enlazar este ítem:
http://hdl.handle.net/10201/19033
Twittear
Título: | hu-PBL-SCID mice: an in vivo model of Epstein-Barr virus-dependent lymphoproliferative disease |
Fecha de publicación: | 1998 |
Editorial: | Murcia : F. Hernández |
ISSN: | 0213-3911 |
Materias relacionadas: | CDU::6 - Ciencias aplicadas::61 - Medicina |
Palabras clave: | Epstein-Barr virus Lymphoproliferative disease |
Resumen: | The Epstein-Barr virus (EBV) exists in most huni:tns as a lifelong latent infection established in host B cells after a primary viral encounter. In immunosuppressed intlivitluals, such as post-transpl~rnt patients, the presence of EBV-infected B cells may lcad to Iq'niplloproliferative disease. Injection of human peripheral blood lymphocytes from EBV-positive clonors into mice wit h severe combined immunodeficiency induces human lymphoproliferative disease i n the recipient closely resembling that of human posttransplant patients. This xenochimeric human-mouse model is increasingly being used to elucidwrc the mcchnnisms of EBV-specific lymphomagenesis and to assess novel therapeutic approaches. |
Autor/es principal/es: | Fuzzati-Armentero, M.T. Duchosal, M.A. |
Forma parte de: | Histology and histopathology |
URI: | http://hdl.handle.net/10201/19033 |
Tipo de documento: | info:eu-repo/semantics/article |
Número páginas / Extensión: | 14 |
Derechos: | info:eu-repo/semantics/openAccess |
Aparece en las colecciones: | Vol.13, nº 1 (1998) |
Ficheros en este ítem:
Fichero | Descripción | Tamaño | Formato | |
---|---|---|---|---|
huPBLSCID mice an in vivo model of EpsteinBarr virus....pdf | 9,31 MB | Adobe PDF | Visualizar/Abrir |
Los ítems de Digitum están protegidos por copyright, con todos los derechos reservados, a menos que se indique lo contrario.