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Título: | Differential signaling through the T cell receptor: from biochemistry to transplantation tolerance |
Fecha de publicación: | 1998 |
Editorial: | Murcia : F. Hernández |
ISSN: | 0213-3911 |
Materias relacionadas: | CDU::6 - Ciencias aplicadas::61 - Medicina |
Palabras clave: | Transplantation T cell tolerance |
Resumen: | Recent advances in our understanding of the structural nature of T cell activation and signal transduction from the T cell receptor for antigen make possible the development of new tolerogenic strategies. Here. we summarize the evidence supporting a critical role for the CO-receptor molecule (CD4 or CD8) and CD45 in determining the pattern of T cell receptormediated signaling. The consequences of this differential signaling can range from T cell proliferation and cytokine production to the establishment of a state of proliferative unresponsiveness known as T cell anergy. Inducing T cell anergy can be an alternative approach for the establishment of transplantation tolerance. |
Autor/es principal/es: | Madrenas, J. Lazarovits, A.I. |
Forma parte de: | Histology and histopathology |
URI: | http://hdl.handle.net/10201/19027 |
Tipo de documento: | info:eu-repo/semantics/article |
Número páginas / Extensión: | 9 |
Derechos: | info:eu-repo/semantics/openAccess |
Aparece en las colecciones: | Vol.13, nº 1 (1998) |
Ficheros en este ítem:
Fichero | Descripción | Tamaño | Formato | |
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Differential signaling through the T cell receptor from biochemistry....pdf | 6,22 MB | Adobe PDF | Visualizar/Abrir |
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