Please use this identifier to cite or link to this item: http://hdl.handle.net/10201/18956

Title: Objective differential classification of thyroid lesions by nuclear quantitative assessment
Issue Date: 1997
Publisher: Murcia : F. Hernández
ISSN: 0213-3911
Related subjects: CDU::6 - Ciencias aplicadas::61 - Medicina
Keywords: Thyroid lesions
Quantitative microscopy
Abstract: Quantitative nuclear parameters estimated by morphometric and stereological methods in combination with discriminant analysis were used in order to evaluate the diagnostic efficiency of thyroid lesions. This study includes 55 patients with thyroid pathology. Samples of follicular adenomas, follicular carcinoma, and papillary carcinomas were exarnined by image analysis to obtain size and form nuclear parameters. Stepwise discriminant analyses were performed. There was an increase in nuclear size from follicular adenomas to follicular carcinomas, and a greater increase from follicular carcinomas to papillary carcinomas. The increase was more significant when the three-dimensional estimates of the volume-weighted mean nuclear volume were assessed. No significant differences between follicular adenomas and follicular carcinomas were found with respect to the nuclear form factors; however, a significant increase in nuclear elongation and irregularity was registered between follicular and papillary tumors (pe0.01). The overall accuracy rate of discrimination was 75% when the three lesions were included in the analysis, with an efficiency of 85% for papillary carcinoma samples. These percentages increased when two lesion discrimination was performed. The worst discrimination (69% of efficiency) was found between follicular adenomas and follicular carcinomas.
Primary author: Artacho-Perula, E.
Roldan-Villalobos, R.
Blanco-García, F.
Blanco Rodriguez, A.
Published in: Histology and histopathology
URI: http://hdl.handle.net/10201/18956
Document type: info:eu-repo/semantics/article
Number of pages / Extensions: 7
Rights: info:eu-repo/semantics/openAccess
Appears in Collections:Vol.12, nº 2 (1997)



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