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Title: Collagen types Vlll and X, two non-fibrillar, short-chain collagens. Structure homologies, functions and involvement in pathology
Issue Date: 1997
Publisher: Murcia : F. Hernández
ISSN: 0213-3911
Related subjects: CDU::6 - Ciencias aplicadas::61 - Medicina
Keywords: Short-chain collagens
Collagen type VIII
Abstract: . Collagens can be divided into two groups, Le., fibrillar and non-fibrillar collagens. Short-chain collagens, a subgroup of non-fibrillar collagens, comprises collagen type VI11 and type X. These two collagen types show severa1 similarities in stnicture and possibly also in function. Type VI11 collagen appears to be secreted by rapidly proliferating cells. It can be found in basement membranes and may serve as a molecular bridge between different types of matrix molecules. In different tissues this collagen type may serve different functions. Stabilization of membranes, angiogenesis, and interactions with other extracellular matrix molecules. Since collagen type X is produced by hypertrophic chondrocytes, this collagen type can only be found in matrix of the hypertrophic zone of the epiphyseal growth plate cartilage. Collagen type X is probably involved in the process of mineralization, endochondral ossification, and is also proposed to play a role in angiogenesis. Collagen types VI1 and X may be involved in matrix and bone disorders. Their structure, function, and involvement in pathology are discussed in this review.
Primary author: Sutmulle, M.
Bruijn, J.A.
De Heer, E.
Published in: Histology and histopathology
Document type: info:eu-repo/semantics/article
Number of pages / Extensions: 10
Rights: info:eu-repo/semantics/openAccess
Appears in Collections:Vol.12, nº 2 (1997)

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