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Título: | Roles of integrins in fibronectin matrix assembly |
Fecha de publicación: | 1997 |
Editorial: | Murcia : F. Hernández |
ISSN: | 0213-3911 |
Materias relacionadas: | CDU::5 - Ciencias puras y naturales::57 - Biología::577 - Bioquímica. Biología molecular. Biofísica |
Palabras clave: | Integrins Fibronectins |
Resumen: | Fibronectin (Fn) matrix assembly is a dynamic cellular process in which the soluble dimeric Fn molecules are assembled into insoluble, disulfide bond stabilized fibrillar polymeric matrix. Fn matrix assembly requires specific Fn binding integrins. Several Fn binding integrins that are capable of mediating Fn matrix assembly have been identified. They include a5B1, aIIbB3 and ctvB3 integrins. Cells regulate the matrix assembly process not only by controlling cell surface expression leve1 of the Fn binding integrins but also by modulating Fn binding and cytoskeleton binding activities of the integrins. A major challenge of future studies is to delineate the signal transduction pathway that regulates Fn matrix assembly |
Autor/es principal/es: | Wu, C. |
Forma parte de: | Histology and histopathology |
URI: | http://hdl.handle.net/10201/18907 |
Tipo de documento: | info:eu-repo/semantics/article |
Número páginas / Extensión: | 8 |
Derechos: | info:eu-repo/semantics/openAccess |
Aparece en las colecciones: | Vol.12, nº 1 (1997) |
Ficheros en este ítem:
Fichero | Descripción | Tamaño | Formato | |
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Roles of integrins in fibronectin matrix assembly.pdf | 4,83 MB | Adobe PDF | Visualizar/Abrir |
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