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Título: | Lectin activities of cytokines and growth factors: function and implications for pathology |
Fecha de publicación: | 1996 |
Editorial: | Murcia : F. Hernández |
ISSN: | 0213-3911 |
Materias relacionadas: | CDU::6 - Ciencias aplicadas::61 - Medicina::615 - Farmacología. Terapéutica. Toxicología. Radiología |
Palabras clave: | Cytokine Clustering |
Resumen: | The discovery that certain cytokines have carbohydrate-binding (lectin) properties opens new concepts in the understanding of their mechanism of action. The carbohydrate-recognition domain, which is localized opposite to the receptor-binding domain, makes these molecules bi-functional. The expression of the biological activity of the cytokine relies on its carbohydrate-binding activity which allows the association of the cytokine receptor with molecular complexes comprising the specific kinase involved in receptor phosphorylation and in specific signal transduction. It is expected that blood accumulation of free or membrane-bound glycan ligands of cytokines may dramatically perturb their endogenous function inducing specific immunodeficiencies. |
Autor/es principal/es: | Zanetta, J.P. Scior, T. Wantyghem, J. Wermuth, C. Aubery, M. Strecker, G. Michalski, J.C. |
Forma parte de: | Histology and histopathology |
URI: | http://hdl.handle.net/10201/18900 |
Tipo de documento: | info:eu-repo/semantics/article |
Número páginas / Extensión: | 8 |
Derechos: | info:eu-repo/semantics/openAccess |
Aparece en las colecciones: | Vol.11, nº 4 (1996) |
Ficheros en este ítem:
Fichero | Descripción | Tamaño | Formato | |
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Lectin activities of cytokines and growth factors function and implications for pathology.pdf | 573,3 kB | Adobe PDF | Visualizar/Abrir |
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