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Título: The retinoblastoma gene family and its role in proliferation, differentiation and development
Fecha de publicación: 1996
Editorial: Murcia : F. Hernández
ISSN: 0213-3911
Materias relacionadas: CDU::6 - Ciencias aplicadas::61 - Medicina::616 - Patología. Medicina clínica. Oncología
Palabras clave: Cell cycle
Genes
Resumen: The retinoblastoma gene family is composed of three members: the retinoblastoma gene, one of the most well studied tumor suppressor genes and two related proteins, p107 and pRb2lp130. These three proteins share many structural and functional features and play a fundamental role in growth control. Intense investieation of these moteins has identified a series of U similar cell-cycle regulators and transcription factors with which they interact. Although the precise function of the retinoblastoma gene product and its relatives remains unknown, recent data suggests that they play parallel roles in controlling cell cycle progression and promoting cellular differentiation. In this review, we will attempt to clarify some of the molecular mechanisms by which these three related proteins cooperate to control cellular proliferation and differentiation.
Autor/es principal/es: De Luca, A.
Esposito, V.
Baldi, A.
Giordano, A.
Publicado en: Histology and histopathology
URI: http://hdl.handle.net/10201/18897
Tipo de documento: info:eu-repo/semantics/article
Número páginas / Extensión: 6
Derechos: info:eu-repo/semantics/openAccess
Aparece en las colecciones:Vol.11, nº 4 (1996)

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