Please use this identifier to cite or link to this item: http://hdl.handle.net/10201/18858

Title: Histoenzymological detection of sialic acids in the rodent salivary glands
Issue Date: 1996
Publisher: Murcia : F. Hernández
ISSN: 0213-3911
Related subjects: CDU::5 - Ciencias puras y naturales::57 - Biología
Keywords: Rodent
Sialic acids
Abstract: Sections from the major salivary glands of rats and mice were used to locate, charactecize and compare sialoglycoconjugates by means of lectin histochemistry, sialidase digestion, periodate oxidation and potassium hydroxide deacetylation. The gland sialylated macromolecules contained the terminal dimers sialic acid-B-galactose and sialic acid-a-N-acetylgalactosamine but differed in the varieties of sialic acids and the linkages of sialic acids to penultimate sugars. Indeed, the submandibular and parotid glands exhibited a notable occurrence of periodate labile sialic acids with C7 andlor C8 andlor C9 acetyl groups in their polyhydroxyl chains. In particular, C9 acetylated sialic acids were mostly linked a2-6 to B-galactose. The sublingual glands, instead, were strongly characterized by a presence of C9 acetylated sialic acids bound a2-3 to B-galactose. Also, sialic acids with O-acetyl substituents at C4 were evident in the mouse parotid gland and in the rat submandibular and sublingual glands. The great variety of sialoderivatives expressed by the rodent salivary glands was correlated with the differential involvement of these compounds in lubricating and defensive processes. Sex-related differences regarding the sialic acid location, acetylation degree and linkage were shown in the submandibular glands of both species.
Primary author: Accili, Daniela
Gabrielli, M.G.
Menghi, Giovanna
Materazzi, G.
Published in: Histology and histopathology
URI: http://hdl.handle.net/10201/18858
Document type: info:eu-repo/semantics/article
Number of pages / Extensions: 12
Rights: info:eu-repo/semantics/openAccess
Appears in Collections:Vol.11, nº 3 (1996)

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