Por favor, use este identificador para citar o enlazar este ítem:
http://hdl.handle.net/10201/18790
Twittear
Título: | A genetic model for undifferentiated cell tumor formation: similar tumors formed by different cell lines transformed by the EIA oncogene |
Fecha de publicación: | 1995 |
Editorial: | Murcia : F. Hernández |
ISSN: | 0213-3911 |
Materias relacionadas: | CDU::6 - Ciencias aplicadas::61 - Medicina |
Palabras clave: | Heterogeneity Undifferentiated tumors |
Resumen: | The activation of oncogenes and the mutation/deletion of supressor genes may be involved in tumor heterogeneity. In an attempt to study tumor heterogeneity, we transformed cell lines from epithelial (PAM 212), mesenchymal (NIH-3T3), or melanocytic origin (L-BIOBR) with the wild type Ela oncogene. To make the cell lines tumorigenic, cells were infected with Harvey sarcoma virus carrying the v-H-ras oncogene. The transformed cells were injected into nude mice and the tumors studied by optical and electron microscopy. The tumors formed by v-H-ras-transformed cells consisted of epitheliod melanomas, spindle cells sarcomas and poorly-differentiated carcinomas, depending on the cell of origin. In contrast, the tumors obtained from cells also carrying the Ela oncogene showed a predominant small and undifferentiated cell pattem regardless of the cell of origin. We conclude that the Ela oncogene products induce a negative control of differentiation, independent of the cell type, and that tumors formed by cells carrying the Ela oncogene display an undifferentiated cell pattem. |
Autor/es principal/es: | Ramón y Cajal, S. Sánchez-Prieto, R. Anaya, A. |
Forma parte de: | Histology and histopathology |
URI: | http://hdl.handle.net/10201/18790 |
Tipo de documento: | info:eu-repo/semantics/article |
Número páginas / Extensión: | 10 |
Derechos: | info:eu-repo/semantics/openAccess |
Aparece en las colecciones: | Vol.10, nº 4 (1995) |
Ficheros en este ítem:
Fichero | Descripción | Tamaño | Formato | |
---|---|---|---|---|
A genetic model for undifferentiated cell tumor.pdf | 948,23 kB | Adobe PDF | Visualizar/Abrir |
Los ítems de Digitum están protegidos por copyright, con todos los derechos reservados, a menos que se indique lo contrario.