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Título: | Macrophages in the external muscle layers of mammalian intestines |
Fecha de publicación: | 1995 |
Editorial: | Murcia : F. Hernández |
ISSN: | 0213-3911 |
Materias relacionadas: | CDU::6 - Ciencias aplicadas::61 - Medicina::611 - Anatomía |
Palabras clave: | Small intestine Colon |
Resumen: | The literature on macrophages in the muscularis extema of mouse, rat, guinea pig, cat, dog and human gut is reviewed. In smaller mammals macrophages are regularly situated in two locations: in the serosa and at the level of Auerbach's plexus between the longitudinal and circular muscle layers. In addition a few solitary cells are present at the level of the deep muscular plexus. At the level of Auerbach's plexus the macrophages occur as a constant and regularly distributed cell population with intimate associations between macrophages and interstitial cells of Cajal. Morphologically they differ from most resident macrophages in being irregular in shape with 4-6 primary cytoplasmic processes, which branch and give a stellate appearance. They have been demonstrated with endocytotic markers (trypan red, FWC-dextran, cholera toxin), immunocytochemically with macrophage antibodies (F4180, M1170) and antibodies against MHC class-I1 antigen, GABA and cGMP. In muscularis externa of the human gut a regularly distributed cell population of macrophages is not obvious. However, a phenotypically distinct subgroup is identified by light microscopy with the pan macrophage antibodies (EBM11, C3bl and partly by ~1 5 0 . 9 5a)n~d shows MHC class-I1 antigen. By electron microscopy muscularis extema macrophages, in all species investigated, appear to be endocytically downregulated, and since they are lysozyme, prostaglandine H synthase (both constitutive and activated) and acid phosphatase negative, they appear to be inactivated cells. Both origin and function of these cells are unknown. They may be immunocompetent, participate in a neuroimmune axis, tissue growth and modulation or other regulations of specific cell functions. |
Autor/es principal/es: | Mikkelsen, H.B. |
Forma parte de: | Histology and histopathology |
URI: | http://hdl.handle.net/10201/18768 |
Tipo de documento: | info:eu-repo/semantics/article |
Número páginas / Extensión: | 18 |
Derechos: | info:eu-repo/semantics/openAccess |
Aparece en las colecciones: | Vol.10, nº 3 (1995) |
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Fichero | Descripción | Tamaño | Formato | |
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Macrophages in the external muscle layers of mammalian intestines.pdf | 9,61 MB | Adobe PDF | Visualizar/Abrir |
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