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Título: | Prognostic significance of p53 and c-erbB-2 immunohistochemical evaluation in colorectal adenocarcinoma |
Fecha de publicación: | 1995 |
Editorial: | Murcia : F. Hernández |
ISSN: | 0213-3911 |
Materias relacionadas: | CDU::6 - Ciencias aplicadas::61 - Medicina::616 - Patología. Medicina clínica. Oncología |
Palabras clave: | Colorectal cancer Survival |
Resumen: | Mutant p53 tumour suppressor gene and c-erbB-2 proto-oncogene are involved in human carcinogenesis, and their protein product detection in human malignancies might influence the evolution of many neoplasms. Our aim was to estimate their association with histopathological and clinical parameters of prognostic value in colorectal cancer. An immunohistochemical assay was undertaken in formalin-fixed sections from tissue specimens of 60 colorectal carcinomas. Nuclear p53 expression was detected in 46.6%, while membranic c-erbB-2 positivity was noticed in 35% of the examined cases. P53 positivity rate significantly correlated with poor differentiation (p<0.001), high mitotic activity (p<0.0001), tumour stage (p<0.001) and 5-year overall survival period (p<0.01). C-erbB-2 positivity incidence significantly correlated with advanced Dukes' stage (p<0.001) and high mitotic activity (p<0.05). Significant association between p53 and c-erbB-2 immunostaining was observed (p<0.05) and p531c-erbB-2 CO-expression was related to poor differentiation (p<0.001), high mitotic activity (p<0.00 l), advanced Dukes' stage (p<0.001), tumour aneuploidy (p<0.05) and worse overall survival ( ~ ~ 0 . 0 5 ) . P53 and c-erbB-2 immunohistochemical detection in combination with known prognostic indicators may be a useful future tool in determining colorectal cancer prognosis and subsequently in deciding on optimal postoperative treatments. |
Autor/es principal/es: | Lazaris, A. Ch. Theodoropoulos, G.E. Anastassopoulos, P. Nakopoulou, Lydia Panoussopoulos, D. Papadimitriou, K. |
Forma parte de: | Histology and histopathology |
URI: | http://hdl.handle.net/10201/18758 |
Tipo de documento: | info:eu-repo/semantics/article |
Número páginas / Extensión: | 8 |
Derechos: | info:eu-repo/semantics/openAccess |
Aparece en las colecciones: | Vol.10, nº 3 (1995) |
Ficheros en este ítem:
Fichero | Descripción | Tamaño | Formato | |
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Prognostic significance of p53 and cerbB2 immunohistochemical evaluation in colorectal adenocarcinoma.pdf | 4,64 MB | Adobe PDF | Visualizar/Abrir |
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