Por favor, use este identificador para citar o enlazar este ítem: http://hdl.handle.net/10201/18747

Título: Distribution of immunoreactive transforming growth factor-alpha in non-neoplastic human salivary glands
Fecha de publicación: 1995
Editorial: Murcia : F. Hernández
ISSN: 0213-3911
Materias relacionadas: CDU::6 - Ciencias aplicadas::61 - Medicina::616 - Patología. Medicina clínica. Oncología::616.3 - Patología del aparato digestivo. Odontología
Palabras clave: Salivary gland
Inmunocytochemistry
Resumen: The distribution of immunoreactive transforming growth factor-alpha (TGF-a) was studied in non-neoplastic human major and minor salivary glands using an immunoperoxidase assay in conjuction with an antiserum to human TGF-a. The ductal cell components of all major and minor salivary glands were found to contain significant amounts of TGF-a immunoreactivity. In contrast, acinar and myoepithelial cells consistently lacked immune reaction product in both types of glands. Occasionally, an asynchronous pattern of TGF-a ductal cell immunoreactivity was observed in specific ducts within a section. Also, intraductal secretions, when present, were found to contain TGF-a immunoreactive material. Ductal cells and connective tissue from salivary glands samples showing significant lymphocytic infiltration and loss of acinar cells exhibited higher levels of TGF-a immunoreactivity than normal salivary gland samples. These observations demonstrate, for the first time, the presence of TGF-a immunoreactivity in specific structural components of non-neoplastic human major and minor salivary glands. It will be important in future studies to determine whether alterations in TGF-a expression are detectable in diverse types of salivary gland tumors.
Autor/es principal/es: Ogbureke, K.U.E.
MacDaiel, R.K.
Jacob, R.S.
Durban, E.M.
Forma parte de: Histology and histopathology
URI: http://hdl.handle.net/10201/18747
Tipo de documento: info:eu-repo/semantics/article
Número páginas / Extensión: 6
Derechos: info:eu-repo/semantics/openAccess
Aparece en las colecciones:Vol.10, nº 3 (1995)



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