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Título: | lmmunoreactivity for c-fos and c-myc protein with the monoclonal antibodies 14E10 and 6E10 in malignant mesothelioma and nonneoplastic mesothelium of the pleura |
Fecha de publicación: | 1995 |
Editorial: | Murcia : F. Hernández |
ISSN: | 0213-3911 |
Materias relacionadas: | CDU::6 - Ciencias aplicadas::61 - Medicina::616 - Patología. Medicina clínica. Oncología |
Palabras clave: | Oncogene Pleura |
Resumen: | We studied immunoreactivity for c-fos protein and c-myc protein in malignant mesothelioma (36 cases) and non-neoplastic pleural mesothelium (45 cases) using the murine monoclonal antibodies 14E10 and 6E10. All malignant mesotheliomas and cases with non-neoplastic mesothelium exhibited not only nuclear but also cytoplasmic immunoreactivity for c-fos and cmyc protein in the majority of mesothelial cells. There was no statistically significant difference between the various mesothelioma subtypes or between neoplastic and non-neoplastic mesothelium for c-fos protein immunoreactivity (p>0.05). There was statistically significant difference between neoplastic and nonneoplastic mesothelium for c-myc protein immunoreactivity (p<0.0 1). We conclude that immunoreactivity for c-fos and cmyc protein is present in both non-neoplastic and neoplastic mesothelium, but that a higher proportion of neoplastic mesothelial cells are immunoreactive for cmyc protein when compared with non-neoplastic mesothelium. |
Autor/es principal/es: | Ramael, M. Van den Bossche, J. Buysse, C. Deblier, I. Segers, K. Van Marck, E. |
Forma parte de: | Histology and histopathology |
URI: | http://hdl.handle.net/10201/18743 |
Tipo de documento: | info:eu-repo/semantics/article |
Número páginas / Extensión: | 5 |
Derechos: | info:eu-repo/semantics/openAccess |
Aparece en las colecciones: | Vol.10, nº 3 (1995) |
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lmmunoreactivity for cfos and cmyc protein with the monoclonal antibodies 14E10 and 6E10 in malignant mesothelioma and nonneoplastic.pdf | 3,02 MB | Adobe PDF | Visualizar/Abrir |
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