Giant cell tumor of the ovary. lmmunohistochemical

Abstract

Giant cell tumor (GCT) of the ovary ic a rare condiiion, fouiid almost invariably in the context of a mucinous iumor and presenting a microscopic picture indistinguishable frorn GCT of bone. We describe a case of GCT in the wall of a serous cyst of the ovary. An iinmunohistocheniicr~l study was performed using a panel of antibodies to epithelial, niesenchymal and leukocyte antigens. Mononuclear arid giant tumor cells were positive for vimentin; CD 68 and LCA were found only in giant cells whereas actin was only found in inononuclear tumor cells. The immunophenotypic profile of the stronial cells of the residual o\!ary was identical to that of riiononuclear tumor cells. The pi-esentcd data suggest that GCT of the ovary is probnbly ri non-neoplastic lesion of the mesenchyinal stronial cells that react against substances of the associated tuinor or cyst.