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Título: | Modification of swine serum-induced bile duct lesion in BALB/c mice by cyclophosphamide |
Fecha de publicación: | 1990 |
Editorial: | Murcia: F. Hernández |
ISSN: | 0213-3911 |
Materias relacionadas: | CDU::6 - Ciencias aplicadas::61 - Medicina |
Palabras clave: | Swine serum Cyclophosphamide |
Resumen: | Effects of cyclophosphamide (CY) on the antibody titer level and incidence and severity of swine serum (SS)-induced bile duct lesion (BDL) were examined. BDL induced by 0.2 m1 of SS per head twice a week for 2 weeks was characterized by hyperplasia of biliary epithelial cells, proliferation of mucous glands, and periductal infiltration of eosinophils with mild fibrosis. CY showed no significant influence on the above-mentioned parameters at the dose levels of 140 and 210 mg/kg. On the other hand, CY lowered the antibody titer level and decreased the seventy of BDL at the dose level of 280 mg/kg, and it suppressed the antibody response and BDL at the dose level of 280 X 2 mg/kg. Thus the antibody titer level and the severity of BDL were closely related each other. |
Autor/es principal/es: | Doi, K. Honjo, K. Doi, C. Mitsuoka, T. |
Forma parte de: | Histology and histopathology, vol. 5, nº2 (1990) |
URI: | http://hdl.handle.net/10201/18551 |
Tipo de documento: | info:eu-repo/semantics/article |
Número páginas / Extensión: | 5 |
Derechos: | info:eu-repo/semantics/openAccess |
Aparece en las colecciones: | Vol. 5, nº 2 (1990) |
Ficheros en este ítem:
Fichero | Descripción | Tamaño | Formato | |
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139-143 Modification of swine serum-induced bile duct lesion in BALBIc mice by cyclophosphamide.pdf | 490,1 kB | Adobe PDF | Visualizar/Abrir |
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