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Title: Modification of swine serum-induced bile duct lesion in BALB/c mice by cyclophosphamide
Issue Date: 1990
Publisher: Murcia: F. Hernández
ISSN: 0213-3911
Related subjects: CDU::6 - Ciencias aplicadas::61 - Medicina
Keywords: Swine serum
Abstract: Effects of cyclophosphamide (CY) on the antibody titer level and incidence and severity of swine serum (SS)-induced bile duct lesion (BDL) were examined. BDL induced by 0.2 m1 of SS per head twice a week for 2 weeks was characterized by hyperplasia of biliary epithelial cells, proliferation of mucous glands, and periductal infiltration of eosinophils with mild fibrosis. CY showed no significant influence on the above-mentioned parameters at the dose levels of 140 and 210 mg/kg. On the other hand, CY lowered the antibody titer level and decreased the seventy of BDL at the dose level of 280 mg/kg, and it suppressed the antibody response and BDL at the dose level of 280 X 2 mg/kg. Thus the antibody titer level and the severity of BDL were closely related each other.
Primary author: Doi, K.
Honjo, K.
Doi, C.
Mitsuoka, T.
Published in: Histology and histopathology, vol. 5, nº2 (1990)
Document type: info:eu-repo/semantics/article
Number of pages / Extensions: 5
Rights: info:eu-repo/semantics/openAccess
Appears in Collections:Vol. 5, nº 2 (1990)

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