Por favor, use este identificador para citar o enlazar este ítem: http://hdl.handle.net/10201/18531

Título: Ischemia-reperfusion of human skeletal muscle during aortoiliac surgery: effects of acetylcarnitine
Fecha de publicación: 1994
Editorial: Murcia : F. Hernández
ISSN: 0213-3911
Materias relacionadas: CDU::6 - Ciencias aplicadas::61 - Medicina
Palabras clave: Skeletal muscle
Resumen: Our previous study on human skeletal muscle undergoing ischemia and reperfusion has revealed that granulocytes, which infiltrate the muscle tissue in large numbers, play an important role in mediating fibre injuries by producing superoxide anion (O?) which is responsible for membrane lipid peroxidation. In the current study, five patients undergoing aortic reconstructive surgery were given acetyl-carnitine (2 mglkg i.v. plus 1 mglkglmin for 30 min) prior to the induction of ischemia. Muscle biopsies and blood samples were examined: a) after anaesthesia; b) at the end of ischemia; and c) 30 min after reperfusion, with the aim of elucidating whether acetylcarnitine could prevent the infiltration andlor the activation of granulocytes and eventually skeletal muscle injuries. During ischemia and reperfusion complement activation recmited numerous granulocytes into the muscle tissue, but, contrary to the untreated samples, the ability for O2 -generation of these cells remained at low levels and was comparable to that of ischemia even when molecular 02 was reintroduced to the tissue. Accordingly, the morphological changes of the postischemic muscle fibers were substantially reduced when compared to the untreated samples; in fact, the mitochondrial swelling was only moderate and the intramitochondrial dense bodies were small and scarce. The current findings support a positive role of acetyl-carnitine in ameliorating the ischernia-reperfusion (1-R)-induced damage of human skeletal muscle.
Autor/es principal/es: Adembri, C.
Lombardo Domenici, L.
Formigli, L.
Brunelleschi, S.
Ferrari, E.
Novelli, G.P.
Forma parte de: Histology and histopathology
URI: http://hdl.handle.net/10201/18531
Tipo de documento: info:eu-repo/semantics/article
Número páginas / Extensión: 8
Derechos: info:eu-repo/semantics/openAccess
Aparece en las colecciones:Vol. 9, nº 4 (1994)

Ficheros en este ítem:
Fichero Descripción TamañoFormato 
Ischemiareperfusion of human skeletal muscle during aortoiliac surgery effects of acetylcarnitine.pdf4,67 MBAdobe PDFVista previa

Los ítems de Digitum están protegidos por copyright, con todos los derechos reservados, a menos que se indique lo contrario.