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dc.contributor.authorCarter, G.T.es_ES
dc.contributor.authorKikuchi, N.es_ES
dc.contributor.authorHorasek, S.J.-
dc.contributor.authorWalsh, S.A.-
dc.description.abstractWe investigated the use of intravenously injected fluorescent dextran molecules (FDx) as a histological marker of sarcolemmal injury. Using fluorescent microscopy, uptake of FDx (average MW 10 kD) was assessed in sections of quadriceps muscles from three models: l ) normal (C57BLlIOSnJ) mice. 2) normal mice run downhill (0, 3, and 7 days post exercise), and 3) non-exercised mdx (dystrophin-deficient) mice. These were compared to serial sections stained with hematoxylin and eosin (H&E). In control muscles. strong fluorescence was seen between fibers (intercellular). Intracellular FDx was observed within cells of the quadriceps from normal mice run downhill at days 0 and 3 post exercise, but not at day 7. On H&E staining. muscle pathology was not observed until day 3, with regeneration by day 7. Intracellular FDx was also observed within mdx muscles, particularly in fibers that appeared pre-necrotic on H&E stained sections. FDx appears to be useful as a histological marker of changes in sarcolemmal integrity associated with muscle injury from eccentric exercise or muscle disease.es_ES
dc.publisherMurcia : F. Hernándezes_ES
dc.relation.ispartofHistology and histopathologyes_ES
dc.subjectMuscle injuryes_ES
dc.subject.otherCDU::6 - Ciencias aplicadas::61 - Medicinaes_ES
dc.titleThe use of fluorescent dextrans as a marker of sarcolemmal injuryes_ES
Aparece en las colecciones:Vol. 9, nº 3 (1994)

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