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Campo DC | Valor | Lengua/Idioma |
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dc.contributor.author | Carter, G.T. | es |
dc.contributor.author | Kikuchi, N. | es |
dc.contributor.author | Horasek, S.J. | - |
dc.contributor.author | Walsh, S.A. | - |
dc.date.accessioned | 2011-02-01T09:18:20Z | - |
dc.date.available | 2011-02-01T09:18:20Z | - |
dc.date.issued | 1994 | - |
dc.identifier.issn | 0213-3911 | es |
dc.identifier.uri | http://hdl.handle.net/10201/18517 | - |
dc.description.abstract | We investigated the use of intravenously injected fluorescent dextran molecules (FDx) as a histological marker of sarcolemmal injury. Using fluorescent microscopy, uptake of FDx (average MW 10 kD) was assessed in sections of quadriceps muscles from three models: l ) normal (C57BLlIOSnJ) mice. 2) normal mice run downhill (0, 3, and 7 days post exercise), and 3) non-exercised mdx (dystrophin-deficient) mice. These were compared to serial sections stained with hematoxylin and eosin (H&E). In control muscles. strong fluorescence was seen between fibers (intercellular). Intracellular FDx was observed within cells of the quadriceps from normal mice run downhill at days 0 and 3 post exercise, but not at day 7. On H&E staining. muscle pathology was not observed until day 3, with regeneration by day 7. Intracellular FDx was also observed within mdx muscles, particularly in fibers that appeared pre-necrotic on H&E stained sections. FDx appears to be useful as a histological marker of changes in sarcolemmal integrity associated with muscle injury from eccentric exercise or muscle disease. | es |
dc.format | application/pdf | es |
dc.format.extent | 5 | es |
dc.language | eng | es |
dc.publisher | Murcia : F. Hernández | es |
dc.relation.ispartof | Histology and histopathology | es |
dc.rights | info:eu-repo/semantics/openAccess | es |
dc.subject | Muscle injury | es |
dc.subject | Histology | es |
dc.subject.other | CDU::6 - Ciencias aplicadas::61 - Medicina | es |
dc.title | The use of fluorescent dextrans as a marker of sarcolemmal injury | es |
dc.type | info:eu-repo/semantics/article | es |
Aparece en las colecciones: | Vol. 9, nº 3 (1994) |
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The use of fluorescent dextrans as a marker of sarcolemmal injury.pdf | 422,55 kB | Adobe PDF | Visualizar/Abrir |
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