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dc.contributor.authorLogothetou-Rella, H.es_ES
dc.date.accessioned2011-02-01T09:18:18Z-
dc.date.available2011-02-01T09:18:18Z-
dc.date.issued1994-
dc.identifier.issn0213-3911es_ES
dc.identifier.urihttp://hdl.handle.net/10201/18515-
dc.description.abstractPhytohaemagglutinin (PHA)-activated lymphocytes differentiated into nuclear vlimata (NVs) in vitro. Lymphocyte attachment was followed by formation and extrusion of cytoplasmic vesicles. nuclear elongation and fragmentation into NVs. NVs and cytoplasmic vesicles were detached and organized into large cell nodules in suspension. Immunocytochemistry showed that T-lymphocytes differentiated mainly to NVs while B-lymphocytes to buds. During differentiation there was a loss or gain of T-antigenicity by either mother or daughter cell. Cytogenetic analysis by chromosomal spreading and in situ techniques showed that NVs do carry chromosomes of hypodiploid or hypohaploid sets. NVs were the result of meiosis stimulated by PHA. A ly~nphocyticp opulation exhibited diploidies attributed to mitosis or symmetrical meiosis and hypodiploidies, hypohaploidies attributed to meiosis. A comparison between NVs and spermatozoa was provided. The inhibitor of calcium-activated neutral proteinase (CANP-I) was cytotoxic to NVs without interfering with NV production. A model was proposed for the action of CANP-I which is a promising agent against autoimmune diseases.es_ES
dc.formatapplication/pdfes_ES
dc.format.extent16es_ES
dc.languageenges_ES
dc.publisherMurcia : F. Hernándezes_ES
dc.relation.ispartofHistology and histopathologyes_ES
dc.rightsinfo:eu-repo/semantics/openAccesses_ES
dc.subjectLymphocytees_ES
dc.subjectCytogeneticses_ES
dc.subject.otherCDU::6 - Ciencias aplicadas::61 - Medicinaes_ES
dc.titleDifferentiation of human lymphocytes into nuclear vlimata by meiosis. The cytotoxic effect of calcium-activated neutral proteinase inhibitores_ES
dc.typeinfo:eu-repo/semantics/articlees_ES
Aparece en las colecciones:Vol. 9, nº 3 (1994)



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