Por favor, use este identificador para citar o enlazar este ítem:
http://hdl.handle.net/10201/18452
Twittear
Título: | «Neuroendocrine» differentiation in hepatocellular carcinomas (HCCs): lmmunohistochemical reactivity is related to distinct tumor cell types, but not to tumor grade |
Fecha de publicación: | 1993 |
Editorial: | Murcia : F. Hernández |
ISSN: | 0213-3911 |
Materias relacionadas: | CDU::6 - Ciencias aplicadas::61 - Medicina::616 - Patología. Medicina clínica. Oncología |
Palabras clave: | Neuroendocrine cells Hepatocellular carcinoma |
Resumen: | We have analyzed neuroendocrine differentiation (ND) in hepatocellular carcinomas (HCCs) of fifty patients. It turned out that ND is frequent in HCCs, and that it is not restricted to fibrolamellar hepatocellular carcinoma (FL-HCC). Multiexpression is seen in a quarter of the cases, and marker coexpression may occur within the same tumor cell. ND predominates in trabecular and rnixed HCCs, but does not appear to be related to grade. Most positive cases showed a hepatocyte-like cell morphology, frequently associated with bile formation. It thus appears that the HCC cell type most likely to show ND is a hepatocyte-like one, i.e. differentiated cell, frequently polarized and producing bile, rather than a small and poorly-differentiated cell. Possible pathogenic mechanisms leading to ND in HCCs are briefly discussed. |
Autor/es principal/es: | Zhao, M. Laissue, J.A. Zimmermann, Astrid |
Forma parte de: | Histology and histopathology |
URI: | http://hdl.handle.net/10201/18452 |
Tipo de documento: | info:eu-repo/semantics/article |
Número páginas / Extensión: | 10 |
Derechos: | info:eu-repo/semantics/openAccess |
Aparece en las colecciones: | Vol. 8, nº 4 (1993) |
Ficheros en este ítem:
Fichero | Descripción | Tamaño | Formato | |
---|---|---|---|---|
Neuroendocrine differentiation in hepatocellular carcinomas HCCs lmmunohistochemical reactivity is related to distinct tumor cell.pdf | 1,68 MB | Adobe PDF | Visualizar/Abrir |
Los ítems de Digitum están protegidos por copyright, con todos los derechos reservados, a menos que se indique lo contrario.