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Título: | Tumor-infiltrating lymphocytes expressing IOT-10 marker. An immunohistochemical study of a series of 185 brain tumors |
Fecha de publicación: | 1993 |
Editorial: | Murcia : F. Hernández |
ISSN: | 0213-3911 |
Materias relacionadas: | CDU::6 - Ciencias aplicadas::61 - Medicina::616 - Patología. Medicina clínica. Oncología::616.8 - Neurología. Neuropatología. Sistema nervioso |
Palabras clave: | Immunohistochemistry Brain tumors |
Resumen: | The presence of IOT-10-positive lymphocytes among the tumor-infiltrating-lymphocyte (TIL) population was studied in a series of 185 brain tumors. In most of the tumors, IOT-10-positive lymphocytes were identified, but generally they were scarce and masked among the tumor cells, suggesting that NK-cells exercise a poor participation in the tissular response against brain tumors. Isolated tumor cells showing IOT- 10-positivity were found in low-grade astrocytomas, neurinomas and medulloblastomas. IOT- 10-positivity on both tumor neuropil and tumor cells was considered a characteristic finding in oligodendrogliomas. The number of IOT- 10-positive NK-cells in brain metastases and in cerebellar hemangioblastomas was comparatively greater than in other types of brain tumor. Since in brain metastases, the presence of IOT-10-positive NK-cells can be related to the tissular response to an extracerebral malignancy, their considerable presence in cerebellar hemangioblastomas is an enigmatic finding that desemes further attention. |
Autor/es principal/es: | Zurita, M. Vaquero, J. Coca, S. Oya, S. García, N . |
Forma parte de: | Histology and histopathology |
URI: | http://hdl.handle.net/10201/18404 |
Tipo de documento: | info:eu-repo/semantics/article |
Número páginas / Extensión: | 6 |
Derechos: | info:eu-repo/semantics/openAccess |
Aparece en las colecciones: | Vol. 8, nº 2 (1993) |
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Tumorinfiltrating lymphocytes expressing IOT10 marker. An immunohistochemical study of a series of 185 brain tumors.pdf | 3,61 MB | Adobe PDF | Visualizar/Abrir |
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