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http://hdl.handle.net/10201/18348
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Campo DC | Valor | Lengua/Idioma |
---|---|---|
dc.contributor.author | López-García, Carlos | es |
dc.contributor.author | Molowny, A. | es |
dc.contributor.author | Martínez Guijarro, F.J. | - |
dc.contributor.author | Blasco-lbáñez, J.M. | - |
dc.contributor.author | Luis de la Iglesia, J.A. | - |
dc.contributor.author | Bernabeu, A. | - |
dc.contributor.author | García-Verdugo, J.M. | - |
dc.date.accessioned | 2011-02-01T08:47:48Z | - |
dc.date.available | 2011-02-01T08:47:48Z | - |
dc.date.issued | 1992 | - |
dc.identifier.issn | 0213-3911 | es |
dc.identifier.uri | http://hdl.handle.net/10201/18348 | - |
dc.description.abstract | The cerebral cortex of Squamate reptiles (lizards and snakes) may be regarded as an archicortex or ereptilian hippocampus». In lizards, one cortical area, the media1 cortex, may be considered as a true ~fascia dentata» on grounds of its anatomy, connectivity and cyto- chemo-architectonics of its main zinc-rich axonal projection. Moreover, its late ontogenesis and postnatal development support this view. In normal conditions, it shows delayed postnatal neurogenesis and growth during the lizard's life span. Remnant neuroblasts in the media1 cortical ependyma of adult lizards seasonally proliferate. The late-produced immature neurocytes migrate to the medial cortex cell layer where they differentiate and give off zinc-containing axons directed to the rest of cortical areas. This results in a continuous growth of the medial cortex and its zinc-rich axonal projection. Perhaps the most important characteristic of the lizard medial cortex is that it can regenerate after having been almost completely destroyed. Recent experiments in our laboratory have shown that chemical lesion of its neurons (up to 95%) results in a cascade of events; first, those related with massive neuronal death and axonal-dendritic retraction and, secondly, those related with a triggered neuroblast proliferation and subsequent neohistogenesis, and the regeneration of an almost new medial cortex that shows itself undistinguishable from a normal undamaged one. This is the only report to our knowledge that an arnniote central nervous centre may regenerate by new neuron production and neo-histogenesis. Perhaps the media1 cortex of lizards may be used as a model for neuronal regeneration andlor transplant experiments in mammals or even in primates. | es |
dc.format | application/pdf | es |
dc.format.extent | 22 | es |
dc.language | eng | es |
dc.publisher | Murcia : F. Hernández | es |
dc.relation.ispartof | Histology and histopathology | es |
dc.rights | info:eu-repo/semantics/openAccess | es |
dc.subject | Cerebral cortex | es |
dc.subject | Reptiles | es |
dc.subject.other | CDU::5 - Ciencias puras y naturales::57 - Biología::576 - Biología celular y subcelular. Citología | es |
dc.title | Lesion and regeneration in the medical cerebral cortex of lizards | es |
dc.type | info:eu-repo/semantics/article | es |
Aparece en las colecciones: | Vol. 7, nº 4 (1992) |
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Lesion and regeneration in the medical cerebral cortex of lizards.pdf | 12,58 MB | Adobe PDF | ![]() Visualizar/Abrir |
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