Please use this identifier to cite or link to this item: http://hdl.handle.net/10201/18345

Title: Morhometric changes in GH-immunoreactive adenohypophyseal cells induced by intraventricular administration of colchicine to adult rats
Issue Date: 1992
Publisher: Murcia : F. Hernández
ISSN: 0213-3911
Related subjects: CDU::6 - Ciencias aplicadas::61 - Medicina::611 - Anatomía
Keywords: Hypophysis
Immunocytochemistry
Abstract: In order to elucidate whether the gender differences observed in the somatotropic cells of adult rats are mediated by hypothalamic neuropeptides, a morphometric analysis was made of the GH-immunoreactive cells of adult rats treated intraventricularly with colchicine. The morphometric and morphological findings obtained were correlated to the basal serum levels of GH at the time of sacrifice. Treatment with colchicine was seen to increase serum GH levels; this increase was accompanied by an increase in the intensity of the reaction of the GH-cells and, morphometrically, an increase in their size due to an increase in the nuclear area, but with no significant changes in the cytoplasmic area. The results suggest that in the absence of somatostatin and GRF the basal release of GH is elevated in a similar fashion in both sexes, in turn suggesting that gonadal steroids might act at hypothalamic leve1 on the release of somatostatin and, indirectly, on the intracellular pool of GH and hormonal secretion.
Primary author: Carretero, J.
Sánchez, F.
Rubio, M.
Juanes, J.A.
Blanco, E.
González, R.
Riesco, J. M.
Vázquez, R.
Published in: Histology and histopathology
URI: http://hdl.handle.net/10201/18345
Document type: info:eu-repo/semantics/article
Number of pages / Extensions: 4
Rights: info:eu-repo/semantics/openAccess
Appears in Collections:Vol. 7, nº 4 (1992)



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