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Título: | Influence of preoperative dexamethasone therapy on proliferating cell nuclear antigen (PCNA) expression in comparison to other parameters in meningiomas |
Fecha de publicación: | 1992 |
Editorial: | Murcia : F. Hernández |
ISSN: | 0213-3911 |
Materias relacionadas: | CDU::6 - Ciencias aplicadas::61 - Medicina::616 - Patología. Medicina clínica. Oncología::616.8 - Neurología. Neuropatología. Sistema nervioso |
Palabras clave: | Meningioma Cell proliferation |
Resumen: | We conducted a trial in 42 benign and malignant meningiomas to assess a possible influence of preoperative dexamethasone therapy on mitotic index, labelling indices of proliferating cell nuclear antigen (PCNA), progesterone receptor, epidermal growth factor receptor (EGF-R), c-erbB-2 oncoprotein, cathepsin D, gamma-gamma enolase as well as the mean number of silver-stained nucleolar organizer region-associated proteins (AgNORs). Tumors with preceding dexamethasone therapy for more than 1 day display significantly less immunohistochemical staining for PCNA. A correlation between the labelling index of PCNA and the degree of malignancy could not be identified. There was no significant effect of preoperative dexamethasone therapy on the other parameters. Our data suggest that dexarnethasone may selectively inhibit the expression of PCNA in the GlISphase of the cell cycle. Thus, we emphasize the necessity to heed factors, e.g. dexamethasone, which may affect the expression of proliferating markers. |
Autor/es principal/es: | Gottschalk, J. Goebel, S. Jautzke, G. Martín, H. Zimmer, C. Marzheuser-Brands, S. Cervós-Navarro, J. |
Forma parte de: | Histology and histopathology |
URI: | http://hdl.handle.net/10201/18340 |
Tipo de documento: | info:eu-repo/semantics/article |
Número páginas / Extensión: | 9 |
Derechos: | info:eu-repo/semantics/openAccess |
Aparece en las colecciones: | Vol. 7, nº 4 (1992) |
Ficheros en este ítem:
Fichero | Descripción | Tamaño | Formato | |
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Influence of preoperative dexamethasone therapy on proliferating cell nuclear antigen PCNA expression in comparison.pdf | 5,31 MB | Adobe PDF | Visualizar/Abrir |
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