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Título: Microvascular pericytes, a review of their morphological and functional characteristics
Fecha de publicación: 1991
Editorial: Murcia : F. Hernández
ISSN: 0213-3911
Materias relacionadas: CDU::6 - Ciencias aplicadas::61 - Medicina
Palabras clave: Pericytes
Resumen: A hundred years after the first description, niany aspects of pericytes reniain to be examined. Mesenchymal in origin, pericytes form an incomplete envelopment around the endothelial cells and within the microvascular basement niernhrane of capillaries and postcapillary venules. Morphologically. they appear as long, slender, polymorphic cells. showing an elongated cell body, from which arise longitudinal and circumferential branches. Cell bodies and cytoplasmic processes of pericytes. as well as the endothelial cells, are enveloped by the same basal lamina. except for where they make direct contacts with each other. The pericytet endothelial cell contacts are peg and socket. adlicsion plaques and gap junctions. making up structural mechanisms for force transmission and a possible receptor system for cells, in which the pcricyte and endothelial cells I-espond to secondary signals generated in the other cells. Electron niicroscopic studies have revealed an elaborate network of cytoplasmic filaments. Pericytc intermediate filament proteins show species and tissue differences. expressing vimentin or vimentin and desmin. The pericytes also express protein typical of contractile cells, i.e. smooth muscle-specific isoforms of actin and myosin, cyclic GMP-protein kinase and tropomyosin. A gradual transition is observed between pericytes and smooth muscle cells in both terminal a-terioles and venules. Several general functions for the pericytes have been postulated: contractability: permeability regulator: integrity maintainer; endothelial cell growth modulator; and cell progenitor with considerable mesenchymal potential.
Autor/es principal/es: Díaz-Flores, Lucio
Gutiérrez, Ricardo
Varela, Hilda
Rancel, N.
Valladares, Francisco
Forma parte de: Histology and histopathology
URI: http://hdl.handle.net/10201/18230
Tipo de documento: info:eu-repo/semantics/article
Número páginas / Extensión: 18
Derechos: info:eu-repo/semantics/openAccess
Aparece en las colecciones:Vol. 6, nº 2 (1991)

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