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Title: lmmunohistochemical demonstration of neuronal and astrocytic markers and oncofoetal antigens in retinoblastomas
Issue Date: 1991
Publisher: Murcia : F. Hernández
ISSN: 0213-3911
Related subjects: CDU::6 - Ciencias aplicadas::61 - Medicina
Keywords: Retinoblastoma
Abstract: General opinion is that retinoblastomas, though not everyone agrees with that view. Some authors suggest that retinoblastomas are derived from a primitive retinal cell able to differentiate into both neuronal and glial cell lines. The aim of tlie present work was to study immunohistocheniically tlie expression of neuronal and astrocytic markers in retinoblastomas and at the same time the presence of tlie oncofoetal antigens carcinocnihryoiiic antigen (CEA) and alpha Focto Protein (AFP). since patients with retinoblastomas often show high oncofoctal antigen in serum levels. For this purpose we cnnployed the strcptavidin-biotin inimunopcroxidase technique in 13 cases of retinobla5toma to evaluate the presence ancl distribution of neuron-specific enolase (NSE). neurofilament protein (NF), glial fihrillary acidic piutein (GFAP), S-l00 protein. CEA and AFP. All 13 tumours \tudicd stained for NSE. Seven of them showed GFAP- and S-l00 positive per ivasc~~lgalri al cells as well as cells distributed randomly in the tuniour that were interpreted as non tumour cells. All 13 retinohlustomas lacked detectable NF, CEA, and AFP. These results \ ~ ~ p p o rtth e idea that retinoblastomas are neuronal tumour\. although retinal glial cells may become incorporated in the tumour and proliferate in response to the t u ~ ~ i o u
Primary author: Antúnez, Jose R.
Couce, Marta
Fraga, Maximo
Garcia-Caballero, Tomas
Beiras, Andres
Perez-Becerra, Eugenio
Forteza, Jeronimo
Published in: Histology and histopathology
Document type: info:eu-repo/semantics/article
Number of pages / Extensions: 6
Rights: info:eu-repo/semantics/openAccess
Appears in Collections:Vol. 6, nº 2 (1991)

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