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Título: Mononuclear cell infiltrate, HLA-Dr expression and proliferation in 37 acoustic schwannomas
Fecha de publicación: 1990
Editorial: Murcia : F. Hernández
ISSN: 0213-3911
Materias relacionadas: CDU::6 - Ciencias aplicadas::61 - Medicina::616 - Patología. Medicina clínica. Oncología::616.8 - Neurología. Neuropatología. Sistema nervioso
Palabras clave: Cellular immunity
Resumen: Frozen sections from 37 schwannomas of the V111 nerve were reacted with a panel of monoclonal antibodies to macrophage, lymphocyte, I-ILA-Dr invariant chain and nuclear proliferation antigens. A moderate number of rnacrophages was demonstrated in 96% of tumours. CD8- and CD4- lymphocytes were detected in slightly smaller numbers in up to 87% and 23% of tumours respectively. B-lyrnphocytes were present in only 2/32 cases and NK-cells were absent from all 16 cases tested. HLA-Dr antigen was expressed by macrophages in most cases and by tumour cells in 13/24 tumours. These findings may represent evidence for a degree of cellular immune response. Occasional cells featuring nuclear proliferation were detected in 15/27 cases.
Autor/es principal/es: Rossi, M.L.
Jones, N.R.
Esiri, M.M.
Havas, L.
Nakamura, N.
Coakham, H.B.
Publicado en: Histology and histopathology
URI: http://hdl.handle.net/10201/18184
Tipo de documento: info:eu-repo/semantics/article
Número páginas / Extensión: 6
Derechos: info:eu-repo/semantics/openAccess
Aparece en las colecciones:Vol. 5, nº 4 (1990)

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