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Title: Serotonin-producing pancreatic endocrine tumour. Histological, ultrastructural and immunohistochemical study of a case
Issue Date: 1990
Publisher: Murcia : F. Hernández
ISSN: 0213-3911
Related subjects: CDU::6 - Ciencias aplicadas::61 - Medicina
Keywords: Immunohistochemistry
Abstract: Serotonin-producing pancreatic endocrine tumours are rare neoplasms which in most cases exhibit malignant biological behaviour. These tumours, in the majority of the well-documented cases, are composed of argyrophil- and argentaffin-positive cells which contain large pleomorphic neurosecretory granules. In contrast, argyrophilic non-argentaffin pancreatic endocrine tumours with tumour cells containing round neurosecretory granules are exceptional. In this study we describe such a tumour not associated with clinical evidence of carcinoid syndrome in a 60-year-old woman. Histological examination revealed tumour extension in pancreatic lymphatic vessels and veins but no evidence of locoregional or distant metastases. Ten months after surgery the patient showed no recurrence of the disease. Immunohistochernistry revealed cytoplasmic serotonin production in the tumour cells which were negative for anti-gastrin, insulin, glucagon, somatostatin, pancreatic polypeptide (PP), vasoactive intestinal peptide (VIP) and ACTH. This study emphasizes the usefulness of combined ultrastructural and immunohistochemical investigations in order to identify and characterize the rare pancreatic endocrine tumours with serotonin production.
Primary author: Kanavaros, Panagiotis
Hoang, Catherine
Le Bodic, Marie Francoise
Polivka, Marc
Hautefeuille, Pierre
Published in: Histology and histopathology
Document type: info:eu-repo/semantics/article
Number of pages / Extensions: 4
Rights: info:eu-repo/semantics/openAccess
Appears in Collections:Vol. 5, nº 3 (1990)

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