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Título: Ground-glass hepatocytes. ligth and electron microscopy. Characterization of the different types
Fecha de publicación: 1990
Editorial: Murcia : F. Hernández
ISSN: 0213-3911
Materias relacionadas: CDU::6 - Ciencias aplicadas::61 - Medicina
Palabras clave: Cyanamide
Ground-glass hepatocytes
Resumen: Morphological observations of paraffinembedded histological sections stained with H&E led to the discovery of some cytoplasmic changes which occur in different conditions, although they look alike under the light microscope. These hepatocytic changes consisted basically of homogeneous areas which are weakly eosinophilic in H & E-stained sections. They are frequently referred to as «inclusion» bodies, even when they are not true inclusions. The hepatocytic changes obsewed in HBsAg carriers, in chronic alcoholic patients treated with cyanamide to discourage them from drinking alcohol, in Lafora's disease, and in glycogenosis type IV, look very similar in paraffin sections stained with H&E. Nevertheless, they can be differentiated using ancillary techniques. On electron microscopy they do not look alike. Of particular interest are the «inclusion» bodies induced by cyanamide, a predictable and reproductible lesion, which in man eventually leads to cirrhosis. Other types of hepatocytic changes also giving a rather vague eground-glass» appearance to the cytoplasm are those resulting from intracytoplasmic accumulation of proteins, particularly fibrinogen, and those observed in patients treated with different drugs.
Autor/es principal/es: Jaime Vázquez, J.
Publicado en: Histology and histopathology
URI: http://hdl.handle.net/10201/18176
Tipo de documento: info:eu-repo/semantics/article
Número páginas / Extensión: 8
Derechos: info:eu-repo/semantics/openAccess
Aparece en las colecciones:Vol. 5, nº 3 (1990)

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