Please use this identifier to cite or link to this item: http://hdl.handle.net/10201/18133

Title: Ulmtrastructuroef the chronically vagotomised atrial myocardiu m in t he mon key (Macaca fascicularis)
Issue Date: 1989
Publisher: Murcia : F. Hernández
ISSN: 0213-3911
Related subjects: CDU::6 - Ciencias aplicadas::61 - Medicina
Keywords: Ultrastructure
Vagotomised
Abstract: The ultrastructure of the atrial myocardium in the monkey (Macaca fascicularis) was studied after bilateral cervical vagotomy and survival times of 100,175 and 367 days. Changes were observed in the nucleus and the cytoplasm of the myocyte. Sequestered within the nuclei of the affected myocytes were cytoplasmic organelles and inclusions. In the late stages, there was a tendency towards condensation and margination of the heterochromatin. Changes in the cytoplasm included increased glycogen, mitochondrial degeneration and myofibrillar disorganisation and degeneration. There was increased collagen and mononuclear cell infiltration in the extracellular space in the later stages. This study has shown that the long term structural integrity of the atrial myocyte depends on an intact vaga1 innervation. The survival of the monkey after chronic bilateral vagotomy suggests that this nonhuman primate is a suitable model for functional studies of the parasympathetically denervated heart.
Primary author: Wong, W. C.
Yick, T. Y.
Ling, E. A.
URI: http://hdl.handle.net/10201/18133
Document type: info:eu-repo/semantics/article
Number of pages / Extensions: 8
Rights: info:eu-repo/semantics/openAccess
Appears in Collections:Vol. 4, nº 3 (1989)



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