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Título: | Effect of dicarboxylic (C, and C,) acids on a human squamous carcinoma cell line in culture |
Fecha de publicación: | 1989 |
Editorial: | Murcia : F. Hernández |
ISSN: | 0213-3911 |
Materias relacionadas: | CDU::6 - Ciencias aplicadas::61 - Medicina |
Palabras clave: | Dicarboxylic acid Squamous carcinoma |
Resumen: | In tissue culture, azelaic acid (C,) has been shown to have an anti-proliferative and cytotoxic effect on human and murine malignant melanocytes, with inhibition of mitochondrial oxido-reductase enzymes and DNA synthesis, and damage to mitochondria. Recent reports of effects on differentiation of normal keratocytes have led to the present study of its effects on a squamous carcinoma cell line. Cells were exposed to single doses of disodium salts of azelaic (CY2Na) and adipic (C,2Na) acids at concentrations of 10-,M and 5 x 10p2M for 48 hrs. Only C,2Na at 5 x 1OP2M for 4 hrs., and longer, significantly affected proliferation, and the cells exhibited massive swelling 6f mitochondria with loss of cristae. The results further confirm the probable value of azelaic acid as a general anti-tumoral agent rather than a specifically melanocytotoxic one. They could justify clinical studies on the effect of topical azelaic acid therapy on squamous cell carcinoma in vivo. |
Autor/es principal/es: | Pätzold, H. C. Breathnach, A. S. Robins, E. J. Daridan, M. E. Bhasin, Y. P. Ethridge, L. B. Nazzaro-Porro, M. Passi, S. Picardo, M. |
URI: | http://hdl.handle.net/10201/18017 |
Tipo de documento: | info:eu-repo/semantics/article |
Número páginas / Extensión: | 5 |
Derechos: | info:eu-repo/semantics/openAccess |
Aparece en las colecciones: | Vol. 4, nº 2 (1989) |
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Effect of dicarboxylic (C6 and C9) acids on a human squamous carcinoma cell line in culture.pdf | 391,33 kB | Adobe PDF | Visualizar/Abrir |
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