Por favor, use este identificador para citar o enlazar este ítem: http://hdl.handle.net/10201/17941

Título: Cytotoxic effects of 3-methylindole on alveolar epithelial cells and macrophages: with special reference to microtubular and filamentous assemblies in alveolar type I cells of bovine lung
Fecha de publicación: 1988
Editorial: Murcia : F. Hernández
ISSN: 0213-3911
Materias relacionadas: CDU::6 - Ciencias aplicadas::61 - Medicina
Palabras clave: Alveolar epithelium
Cytotoxicity
Resumen: The alveolar type I cell is a major permeability barrier between the pulmonary interstitium and alveolar spaces and its thin cytoplasmic processes are greatly susceptible to injury. These cells are often observed to undergo progressive vesiculation, vacuolization and desquamation during 3-methylindole (3MI)-induced acute pulmonary edema after oral administration in goats and cattle. The present study describes proliferation of SER and the presence of polymerized tubulin in the form of microtubules arranged in large bundles shown at ultrastructural level as well as with immunofluorescence staining for tubulin in alveolar type I cells 72 hours after 3MI treatment. Such changes were not seen in pulmonary endothelial cells, alveolar type I1 cells, alveolar macrophages and neutrophils. The possible role of microtubules in alveolar type I cell as a mechanistic support to resist disruption against the forces of interstitial and alveolar edema is compared with alveolar type I1 cells, alveolar macrophages and neutrophils. The latter cells undergo dynamic movements in response to inflammatory stimuli and therefore did not show microtubules in their cytoplasm
Autor/es principal/es: Atwal, Onkar S.
Minhas, Kanwal J.
Perry, Michael S.
Forma parte de: Histology and histopathology
URI: http://hdl.handle.net/10201/17941
Tipo de documento: info:eu-repo/semantics/article
Número páginas / Extensión: 14
Derechos: info:eu-repo/semantics/openAccess
Aparece en las colecciones:Vol. 3, nº 3 (1988)

Ficheros en este ítem:
Fichero Descripción TamañoFormato 
Cytotoxic effects of 3 methylindole on alveolar epithelial cells and macrophages with special ....pdf1,35 MBAdobe PDFVista previa
Visualizar/Abrir


Los ítems de Digitum están protegidos por copyright, con todos los derechos reservados, a menos que se indique lo contrario.