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Título: | Expression of cytokeratin and neuron-specific enolase in small cell carcinomas of the lung |
Fecha de publicación: | 1987 |
Editorial: | Murcia : F. Hernández |
ISSN: | 0213-3911 |
Materias relacionadas: | CDU::6 - Ciencias aplicadas::61 - Medicina |
Palabras clave: | Small cell carcinoma Cytokeratin |
Resumen: | Using a polyclonal antibody against human epidermal keratins and a monoclonal antibody against cytokeratins characteristic of simple epithelia, and the Avidin-Biotin system of immunohistochemistry, we have demonstrated cytokeratin expression in 46% and in 60% of small cell carcinomas of the lung at autopsy respectively. The latter gave a diffuse stronger reaction product than the polyclonal antibody. The results suggest that there is a cytokeratin rich and a cytokeratin poor type of small cell carcinoma. Neuron-specific enolase immunohistochemistry was positive in 60% of the cases. Coexpression with cytokeratin was seen in ten cases (30%). The expression of cytokeratin and neuronspecific enolase in small cell carcinomas strongly suggests that they are of an epithelial origin, but are capable of neuroendocrine differentiation. |
Autor/es principal/es: | Kitinya, James N. Mitsuru Kingo Kenzo Tanaka |
Forma parte de: | Histology and histopathology |
URI: | http://hdl.handle.net/10201/17895 |
Tipo de documento: | info:eu-repo/semantics/article |
Número páginas / Extensión: | 11 |
Derechos: | info:eu-repo/semantics/openAccess |
Aparece en las colecciones: | Vol. 2, nº 4 (1987) |
Ficheros en este ítem:
Fichero | Descripción | Tamaño | Formato | |
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Expression of cytokeratin and neuronspecific enolase in small cell carcinomas of the lung.pdf | 868,88 kB | Adobe PDF | Visualizar/Abrir |
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