Glomerular histopathology of the contralateral kidney in experimental unilateral hydronephrosis

Abstract

The aim of this study was to examine the structural, ultrastructural and morphometric alterations which take place in the contralateral kidneys of rats with experimental unilateral hydronephrosis. 20 Wistar rats weighing 250 gr., affected by a process of unilateral hydronephrosis following the ligature of the ureter, were used; these rats were then killed 40,50,60, or 70 days after the ligature. Among the perceived alterations, were immunoglobulin G deposits shown by positive immunoperoxidase reaction and increase in the size of the glomerular and corpuscle from around the fortieth day, and structural alterations that included the pedicels, electrondense deposits in the podocytes and pseudogranular structures in the basal membrane of the capillary.