Effects of Friend leukemia virus (FLV) inoculation in F1 mice and differentiation of FLV-induced leukemia

Abstract

Effects of Friend leukemia virus (FLV) inoculation in F, specific pathogen free (SPF) mice were examined. Resistance to FLV was dominantly inherited both in F, hybrid mice (BDF,) (FLV-resistant & FLVsensitive with polycythemia) and F, hybrid mice (B6C3FI) (FLV-resitant & FLV-sensitive with anemia). But the population dynamics of the nucleated cell components of F, mice after FLV inoculation differed from those of FLV-resistant inbred mice. A small number of mature erythroblasts appeared in the peripheral blood of BDF, mice. In B6C3FI mice, erythroblastosis with splenomegaly and polycythemia occurred. However, all of these findings in BDF, and B6C3FI mice regressed spontaneously. In F, mice, FLV induced an intermediate reactive pattern of the two patterns that had been induced in the parental strains. The results indicate that FLV may induce leukemia with various degrees of differentiation, according to the genetic difference of the host.