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|Título:||Substance P-like immunoreactivity in rat and cat carotid bodies, Light and electron microscopic studies|
|Fecha de publicación:||1986|
|Editorial:||Murcia : F. Hernández|
|Materias relacionadas:||CDU::6 - Ciencias aplicadas::61 - Medicina|
|Palabras clave:||Carotid body|
|Resumen:||Substance P-immunoreactive (SP-I) structures in the carotid bodies of rats and cats were examined with the light and electron microscopes. In both species SP-I varicose nerve fibers were located singly in the interstitial connective tissue in close association with blood vessels. They were small unmyelinated fibers enveloped in a common Schwann cell sheath with other SP-negative fibers. Some of SP-I fibers contained large dense-cored granules and small clear vesicles in addition to microtubules and mitochondria and probably represented nerve fiber varicosities. The latter often were found incompletely invested by Schwann cell sheaths. SP-fibers were found occasionally in the envelopes of supporting cells at the periphery of parenchymal cell groups. However, none of the nerve terminals making synaptic contacts with glomus cells exhibited SP-like immunoreactivity. In cat carotid bodies some glomus cells showed moderate to intense SPlike immunoreactivity.The intense SP-I glomus cells displayed numerous dense-cored vesicles of 85 to 140 nm in diameter and frequently showed synaptic contacts with SP-negative nerve terminals. In rat carotid bodies we were unable to detect consistent SP-immunoreactivity in glomus cells. Our results do not favor the hypothesis that SP is a neurotransmitter/modulator in the chemoreceptor afferents synapsing on glomus cells in either the cat or rat carotid body. However our results support the hypothesis that SP in cat glomus cells may play a role in the modulation of chemoreceptor activity.|
|Autor/es principal/es:||I-li Chen|
Yates, Robert D.
Hansen, John T.
|Publicado en:||Histology and histopathology|
|Tipo de documento:||info:eu-repo/semantics/article|
|Número páginas / Extensión:||10|
|Aparece en las colecciones:||Vol. 1, nº 3 (1986)|
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|Substance Plike immunoreactivity in rat and cat carotid bodies Light and electron microscopic studies.pdf||1,31 MB||Adobe PDF|
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