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Título: In vitro and in vivo efficacy evaluation of new self-assembling curcumin loaded nanohyaluronan-glycerosomes on wound restoring in health and diabetic rats
Fecha de defensa / creación: 26-may-2025
Editorial: Elsevier
Cita bibliográfica: International Journal of Biological Macromolecules (2024)
ISSN: Print: 0141-8130
Electronic1879-0003
Palabras clave: Wound healing
Rats
Curcumin
Liposomes
Hyaluronic acid
Diabetic wounds
Nanohydrogel
Resumen: In this study the wound healing efficacy of new self-assembling curcumin loaded nanohyaluronan-glycerosomes has been tested in healthy and diabetic rats. Curcumin was loaded in nanohyaluronan-liposomes and -glycerosomes, special vesicles obtained mixing curcumin, hyaluronan nanohydrogel and soy lecithin. Curcumin loaded liposomes and glycerosomes were also prepared, characterized and tested as references. The physico-chemical (size and size distribution, surface charge and morphology), and technological (entrapment efficiency, stability over time and skin delivery) characteristics and biological performances (safety, ability to protect in vitro cells from oxidative damage) of prepared formulations were measured. Finally, they were daily applied to skin wounds of healthy or diabetic rats. The animal skin was excided and analysed at days 3, 7 and 14. The macroscopic observation underlined the higher ability of curcumin loaded nanohyaluronan-glycerosomes to improve wound healing in diabetic rats, already on day 3 up to day 14 (p < 0.05). Histopathological analysis confirmed an accelerated re-epithelization in healthy rats, while increased angiogenesis in diabetic ones. The superior therapeutic efficacy of curcumin loaded nanohyaluronan-glycerosomes compared to other formulations can be related to their enhanced ability to deliver higher curcumin concentrations at the wound site due to a synergistic effect of glycerol, hyaluronan nanohydrogel and lecithin.
Autor/es principal/es: Gómez García, Francisco José
Ramírez Andreo, Antonio
Manconi, María
Manca, María Letizia
Matricardi, Pietro
Di Meo, Chiara
Fernàndez-Busquets, Xavier
Martínez Díaz, Francisco
Salmerón Martínez, Diego
López Jornet, Pía
Versión del editor: https://www.sciencedirect.com/science/article/pii/S0141813025052511?via%3Dihub
URI: http://hdl.handle.net/10201/155341
DOI: https://doi.org/10.1016/j.ijbiomac.2025.144699
Tipo de documento: info:eu-repo/semantics/article
Número páginas / Extensión: 34
Derechos: info:eu-repo/semantics/openAccess
Attribution-NonCommercial-NoDerivatives 4.0 Internacional
Descripción: © 2025, Published by Elsevier B.V. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/. This document is the Published version of a Published Work that appeared in final form in International Journal of Biological Macromolecules. To access the final edited and published work see https://doi.org/10.1016/j.ijbiomac.2025.144699
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