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Título: Broccoli byproduct extracts attenuate the expression of UVB-induced proinflammatory cytokines in HaCaT keratinocytes
Fecha de publicación: 2-dic-2024
Editorial: MDPI
Cita bibliográfica: Antioxidants, 2024, Vol. 13 (12) : 1479
ISSN: Electronic: 2076-3921
Palabras clave: Broccoli byproducts
Proinflammatory cytokines
Reactive oxygen species
Skin wound repair
Supercritical fluid extraction
UVB radiation
Resumen: Broccoli byproducts are an important source of bioactive compounds, which provide important benefits for human skin due mainly to their antioxidant and anti-inflammatory properties. The primary target of UVB radiation is the basal layer of cells in the epidermis, with keratinocytes being the most abundant cell population in this layer. Given the wide range of side effects caused by exposure to UVB radiation, reducing the amount of UV light that penetrates the skin and strengthening the protective mechanisms of the skin are interesting strategies for the prevention of skin disorders. This work aims to evaluate the protective mechanisms triggered by broccoli by-products extract (BBE) on HaCaT keratinocytes exposed to UVB radiation as well as the study of the regenerative effect of these extracts on the barrier of skin keratinocytes damaged by superficial wounds as a strategy to revalorize this agricultural waste. The results obtained revealed that the BBEs exhibited a high cytoprotective effect on the HaCaT exposed to UVB light, allowing it to effectively reduce the intracellular content of ROS, as well as effectively attenuating the increase in proinflammatory cytokines (IL-1β, IL-6, IL-78, TNF-α) and COX-2 induced by this type of radiation. Furthermore, the BBE could be an excellent regenerative agent for skin wound repair, accelerating the migration capacity of keratinocytes thus contributing to the valorization of this byproduct as a valuable ingredient in cosmetic formulations.
Autor/es principal/es: Borja Martínez, María
Pedreño, María Angeles
Sabater Jara, Ana Belén
Versión del editor: https://www.mdpi.com/2076-3921/13/12/1479
URI: http://hdl.handle.net/10201/154786
DOI: https://doi.org/10.3390/ antiox13121479
Tipo de documento: info:eu-repo/semantics/article
Número páginas / Extensión: 16
Derechos: info:eu-repo/semantics/openAccess
Atribución 4.0 Internacional
Descripción: © 2024 by the authors. This manuscript version is made available under the CC-BY 4.0 license http://creativecommons.org/licenses/by/4.0/ This document is the Published Manuscript version of a Published Work that appeared in final form in Antioxidants. To access the final edited and published work see https://doi.org/10.3390/antiox13121479
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