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Título: Antimicrobial susceptibility of Rhodococcus equi strains isolated from foals in Chile
Fecha de publicación: 22-jun-2023
Cita bibliográfica: World Journal of Microbiology and Biotechnology (2023) 39:231
ISSN: Print: 0959-3993
Electronic: 1573-0972
Palabras clave: Antimicrobial susceptibility
Foals
Macrolides
Rhodoccocus equi
Resumen: Rhodococcus equi is responsible for foal pneumonia worldwide, with a significant economic impact on the production and breeding of horses. In Chile, the first case was reported in 2000, and since then, its incidence has been increasing. Distinctive characteristics of R. equi as an intracellular pathogen in macrophages, emergence of virulence plasmids encoding surface lipoprotein antigens, and appearance of antibiotic resistance against macrolides and rifampicin have significantly complicated the treatment of R. equi pneumonia in foals. Therefore, in vitro susceptibility studies of first-line and newer antibiotics against R. equi are the first step to establishing effective treatments and optimizing new therapeutic options. The aim of the present study is to determine the susceptibility profile of fourteen strains of R. equi isolated from foals in Chile to several antibiotics of the macrolide group including azithromycin, amikacin, tildipirosin and gamithromycin as well as others such as rifampicin, doxycycline and ceftiofur. Identification of R. equi in collected isolates from foals in Chile has been performed by CAMP test and PCR based on detecting of the gene encoding the 16 S rRNA. The presence of genes encoding virulence plasmids was also determined using PCR. Results obtained have demonstrated presence of virulent R. equi strains in Chile. In vitro susceptibility pattern to different antibiotics has shown better results for doxycycline and rifampicin similar to previous studies performed. Current macrolides have been evaluated in order to consider alternative treatment options in a context of emerging resistance to classic macrolides and rifampicin, obtaining better results with gamithromycin (MIC range of 0.125 to 128 mg/ml) than with tildipirosin (MIC range of 16 to 128 mg/ml). An adequate diagnosis of bacterial susceptibility based on antibiograms is necessary to treat the Rhodococcus equi infection in foals.
Autor/es principal/es: Badillo Puerta, Elena
Zúñiga, María Paz
Abalos, Pedro
Valencia, Eduardo David
Marín, Pedro
Escudero, Elisa
Galecio, Juan Sebastián
Versión del editor: https://link.springer.com/article/10.1007/s11274-023-03677-2
URI: http://hdl.handle.net/10201/152004
DOI: https://doi.org/10.1007/s11274-023-03677-2
Tipo de documento: info:eu-repo/semantics/article
Número páginas / Extensión: 8
Derechos: info:eu-repo/semantics/openAccess
Atribución 4.0 Internacional
Descripción: © The Author(s) 2023. This manuscript version is made available under the CC-BY 4.0 license http://creativecommons.org/licenses/by/4.0/. This document is the Published version of a Published Work that appeared in final form in World Journal of Microbiology and Biotechnology. To access the final edited and published work see https://doi.org/10.1007/s11274-023-03677-2
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