Por favor, use este identificador para citar o enlazar este ítem: https://doi.org/10.1161/HYPERTENSIONAHA.107.100750

Título: Age- and Sodium-Sensitive Hypertension and Sex-Dependent Renal Changes in Rats With a Reduced Nephron Number
Fecha de publicación: 7-feb-2008
Editorial: American Heart Association
Cita bibliográfica: Hypertension, 51(4), 1184-1189
ISSN: Print.: 0194-911X
Electronic.: 1524-4563
Palabras clave: Angiotensin
Renal function
Nephrogenesis
Proteinuria
Resumen: We have demonstrated that the reduction of angiotensin II effects during the nephrogenic period reduces the nephron number and induces the development of hypertension. The hypotheses examined are that this reduction of angiotensin effects leads to the development of an age-dependent sodium sensitive hypertension and that the hypertension is angiotensin II dependent. Newborn rats were treated with an angiotensin II type 1 receptor antagonist during the first 2 weeks of age. At 3 to 4 and 11 to 12 months of age, changes in systolic blood pressure, proteinuria, and renal function in response to a prolonged high sodium intake were examined. The basal blood pressure response to the administration of the angiotensin II receptor antagonist was also evaluated at both ages. Basal blood pressure was similarly elevated (P<0.05) in male and female treated rats, and the increment was age dependent. High sodium intake only elicited a blood pressure elevation (136±1 to 154±3 mm Hg; P<0.05) and a decrease in glomerular filtration rate (28%; P<0.05) at 11 to 12 months in treated rats. Blockade of angiotensin II receptors during renal development induced an increase (P<0.05) in proteinuria that was age and sex dependent, but high sodium intake only induced an elevation in proteinuria in the younger rats (50%; P<0.05). Hypertension was maintained by angiotensin II at both ages because blood pressure decreased to normal levels after treatment with an angiotensin II type 1 receptor antagonist. This study shows that the reduction of angiotensin II effects during the nephrogenic period modifies renal function and induces the development of an angiotensin II–dependent hypertension that becomes sodium sensitive during aging.
Autor/es principal/es: Salazar, Francisco
Reverte, Virginia
Saez, Fara
Lorai, Analia
Llinas, Maria Teresa
Salazar, F. Javier
Versión del editor: https://www.ahajournals.org/doi/10.1161/HYPERTENSIONAHA.107.100750
URI: http://hdl.handle.net/10201/151862
DOI: https://doi.org/10.1161/HYPERTENSIONAHA.107.100750
Tipo de documento: info:eu-repo/semantics/article
Número páginas / Extensión: 6
Derechos: info:eu-repo/semantics/embargoedAccess
Descripción: © 2008 American Heart Association, Inc.. . This document is the published version of a published work that appeared in final form in Hypertension. . To access the final edited and published work see: https://doi.org/10.1161/HYPERTENSIONAHA.107.100750
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