Por favor, use este identificador para citar o enlazar este ítem:
https://doi.org/10.1038/s41589-019-0278-6
Twittear
| Título: | MCC950 closes the active conformation of NLRP3 to an inactive state |
| Fecha de publicación: | jun-2019 |
| Editorial: | Nature Research |
| Cita bibliográfica: | Nature Chemical Biology, 2019, Vol. 15, pp. 60-564 |
| ISSN: | Print: 1552-4450 Electronic: 1552-4469 |
| Materias relacionadas: | CDU::6 - Ciencias aplicadas::61 - Medicina::615 - Farmacología. Terapéutica. Toxicología. Radiología |
| Palabras clave: | NLRP3 Inflammation MCC950 Mechanism of action Antiinflammatory |
| Resumen: | NLRP3 is an innate immune sensor contributing to the development of different diseases including monogenic autoinflammatory syndromes, gout, atherosclerosis, and Alzheimer’s disease. The molecule sulfonylurea MCC950 is a NLRP3 inflammasome inhibitor with potential clinical utility. However, the mechanism of action of MCC950 remains unknown. Here, we characterize the mechanism of action of MCC950 in both wild-type and autoinflammatory-related NLRP3 mutants, demonstrating that MCC950 closes the ‘open’ conformation of active NLRP3. |
| Autor/es principal/es: | Tapia-Abellán, Ana Angosto-Bazarra, Diego Martínez-Banaclocha, Helios Torre-Minguela, Carlos de Cerón-Carrasco, Jose P Pérez-Sánchez, Horacio Arostegui, Juan I Pelegrín Vivancos, Pablo |
| Versión del editor: | https://www.nature.com/articles/s41589-019-0278-6 |
| URI: | http://hdl.handle.net/10201/148834 |
| DOI: | https://doi.org/10.1038/s41589-019-0278-6 |
| Tipo de documento: | info:eu-repo/semantics/article |
| Número páginas / Extensión: | 37 |
| Derechos: | info:eu-repo/semantics/openAccess Attribution-NonCommercial-NoDerivatives 4.0 Internacional |
| Descripción: | © 2019, The Author(s), under exclusive licence to Springer Nature America, Inc. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/ This document is the Accepted Manuscript version of a Published Work that appeared in final form in Nature Chemical Biology. To access the final edited and published work see https://doi.org/10.1038/s41589-019-0278-6 |
| Aparece en las colecciones: | Artículos |
Ficheros en este ítem:
| Fichero | Descripción | Tamaño | Formato | |
|---|---|---|---|---|
| 2019 MCC.pdf | Versión aceptada del artículo | 5,55 MB | Adobe PDF |  Visualizar/Abrir |
Este ítem está sujeto a una licencia Creative Commons Licencia Creative Commons
