Por favor, use este identificador para citar o enlazar este ítem: https://doi.org/10.1152/ajprenal.00394.2018

Título: Sex-dependent differences in the adverse renal changes induced by an early in life exposure to a high-fat diet.
Fecha de publicación: 1-feb-2019
Cita bibliográfica: American Journal Physiology Renal Physiology 316: F332-F340, 2019
ISSN: Print: 1931-857X
Electronic: 1522-1466
Palabras clave: Early obesity
Hypertension
Inflammation
Renal function
Sex dependent
Resumen: This study examines whether the intake of a high-fat diet very early in life leads to changes in arterial pressure and renal function and evaluates whether the mechanisms involved in these changes are sex-dependent. Experiments were performed in male and female Sprague-Dawley rats fed a normal or high-fat diet from weaning to 4 mo of age. This exposure to a high-fat diet lead to an angiotensin II-dependent elevation in arterial pressure and to significant increments in fat abdominal volume and plasma leptin that were similar in both sexes. In addition, the angiotensin II-induced increment in renal vascular resistance was greater ( P < 0.05) in male (106 ± 14%) and female (97 ± 15%) rats fed a high-fat diet than in rats fed a normal-fat diet (51 ± 8%). However, the high-fat intake during early life induced increments in albuminuria, interleukin-6, and infiltration of CD3 lymphocytes in the renal parenchyma that were greater ( P < 0.05) in male than in female rats. Other sex-dependent differences in response to high-fat intake were that adiponectin levels only decreased in females (21%, P < 0.05), and renal NF-κB expression only increased in males (31%, P < 0.05). In summary, the early exposure to a high-fat diet leads to angiotensin II-dependent arterial pressure elevations and to increments in abdominal fat and in the renal sensitivity to angiotensin II that are similar in both sexes. However, the mechanisms involved in the renal changes associated with early exposure to a high-fat diet are different in males and females.
Autor/es principal/es: Moreno Ayuso, Juan Manuel
Tapia, Antonio
Martinez, Carlos Manuel
Reverte, Virginia
Oltra, Lidia
Llinás Más, María Teresa
Salazar, Francisco Javier
Versión del editor: https://journals.physiology.org/doi/full/10.1152/ajprenal.00394.2018
URI: http://hdl.handle.net/10201/148621
DOI: https://doi.org/10.1152/ajprenal.00394.2018
Tipo de documento: info:eu-repo/semantics/article
Número páginas / Extensión: 9
Derechos: info:eu-repo/semantics/embargoedAccess
Descripción: © 2019, the American Physiological Society. This document is the Published version of a published work that appeared in final form in American Journal of Physiology. Renal Physiology. To access the final edited and published work see https://doi.org/10.1152/ajprenal.00394.2018
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