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https://doi.org/10.1152/ajprenal.00394.2018


Título: | Sex-dependent differences in the adverse renal changes induced by an early in life exposure to a high-fat diet. |
Fecha de publicación: | 1-feb-2019 |
Cita bibliográfica: | American Journal Physiology Renal Physiology 316: F332-F340, 2019 |
ISSN: | Print: 1931-857X Electronic: 1522-1466 |
Palabras clave: | Early obesity Hypertension Inflammation Renal function Sex dependent |
Resumen: | This study examines whether the intake of a high-fat diet very early in life leads to changes in arterial pressure and renal function and evaluates whether the mechanisms involved in these changes are sex-dependent. Experiments were performed in male and female Sprague-Dawley rats fed a normal or high-fat diet from weaning to 4 mo of age. This exposure to a high-fat diet lead to an angiotensin II-dependent elevation in arterial pressure and to significant increments in fat abdominal volume and plasma leptin that were similar in both sexes. In addition, the angiotensin II-induced increment in renal vascular resistance was greater ( P < 0.05) in male (106 ± 14%) and female (97 ± 15%) rats fed a high-fat diet than in rats fed a normal-fat diet (51 ± 8%). However, the high-fat intake during early life induced increments in albuminuria, interleukin-6, and infiltration of CD3 lymphocytes in the renal parenchyma that were greater ( P < 0.05) in male than in female rats. Other sex-dependent differences in response to high-fat intake were that adiponectin levels only decreased in females (21%, P < 0.05), and renal NF-κB expression only increased in males (31%, P < 0.05). In summary, the early exposure to a high-fat diet leads to angiotensin II-dependent arterial pressure elevations and to increments in abdominal fat and in the renal sensitivity to angiotensin II that are similar in both sexes. However, the mechanisms involved in the renal changes associated with early exposure to a high-fat diet are different in males and females. |
Autor/es principal/es: | Moreno Ayuso, Juan Manuel Tapia, Antonio Martinez, Carlos Manuel Reverte, Virginia Oltra, Lidia Llinás Más, María Teresa Salazar, Francisco Javier |
Versión del editor: | https://journals.physiology.org/doi/full/10.1152/ajprenal.00394.2018 |
URI: | http://hdl.handle.net/10201/148621 |
DOI: | https://doi.org/10.1152/ajprenal.00394.2018 |
Tipo de documento: | info:eu-repo/semantics/article |
Número páginas / Extensión: | 9 |
Derechos: | info:eu-repo/semantics/embargoedAccess |
Descripción: | © 2019, the American Physiological Society. This document is the Published version of a published work that appeared in final form in American Journal of Physiology. Renal Physiology. To access the final edited and published work see https://doi.org/10.1152/ajprenal.00394.2018 |
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