DNA-Ploidy, morphometric-stereological and P-Glycoprotein study of superficial bladder carcinomas

Abstract

We carried out a DNA-ploidy, morphometri􀀜stereolcgic and P-glycoprotein study on 40 newly diagnosed superficial bladder cancer patients (G l-G2), cor­relating the results with histological grade and clinical outcome. Variations in the number of patients who present recurrences, progression or remain tumor-free during the whole follow-up period (at least 5 years) were not signif­icant when related to nuclear size, proliferative diploid index, presl!nce of aneuploidy and expression of P-glycoprotein. lt is striking how the majority of disease-free subjects showed a proliferative diploid index higher than 10%. Moreoyer .. 3 of them presented a11 aneuploid cell population. In our study, only histological grade showed a significant discriminatory level in terms of progression versus no progression in patients with superficial bladder cancer.