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Título: Purinergic P2X7 receptor expression increases in leukocytes from intra-abdominal septic patients
Fecha de publicación: 29-nov-2023
Editorial: Frontiers Media
Cita bibliográfica: Frontiers in Immunology, 2023, Vol. 14 : 1297249
ISSN: Electronic: 1664-3224
Palabras clave: Sepsis
Inflammation
P2X7 receptor
Purinergic signaling
Danger signals
Leukocytes
Resumen: Inflammation is a tightly coordinated response of the host immune system to bacterial and viral infections, triggered by the production of inflammatory cytokines. Sepsis is defined as a systemic inflammatory response followed by immunosuppression of the host and organ dysfunction. This imbalance of the immune response increases the risk of mortality of patients with sepsis, making it a major problem for critical care units worldwide. The P2X7 receptor plays a crucial role in activating the immune system by inducing the activation of peripheral blood mononuclear cells. In this study, we analyzed a cohort of abdominal origin septic patients and found that the expression of the P2X7 receptor in the plasma membrane is elevated in the different subsets of lymphocytes. We observed a direct relationship between the percentage of P2X7-expressing lymphocytes and the early inflammatory response in sepsis. Additionally, in patients whose lymphocytes presented a higher percentage of P2X7 surface expression, the total lymphocytes populations proportionally decreased. Furthermore, we found a correlation between elevated soluble P2X7 receptors in plasma and inflammasome-dependent cytokine IL-18. In summary, our work demonstrates that P2X7 expression is highly induced in lymphocytes during sepsis, and this correlates with IL-18, along with other inflammatory mediators such as IL-6, IL-8, and procalcitonin.
Autor/es principal/es: Martínez Banaclocha, Helios
García Palenciano, Carlos
Martínez Alarcón, Laura
Amores Iniesta, Joaquín
Martín Sánchez, Fátima
Ercole, Giovanni A.
González Lisorge, Ada
Fernánde Pacheco, José
Martínez Gil, Piedad
Padilla Rodríguez, Julio
Baroja Mazo, Alberto
Pelegrín, Pablo
Martínez García, Juan José
Versión del editor: https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2023.1297249/full
URI: http://hdl.handle.net/10201/145400
DOI: https://doi.org/10.3389/fimmu.2023.1297249
Tipo de documento: info:eu-repo/semantics/article
Número páginas / Extensión: 13
Derechos: info:eu-repo/semantics/openAccess
Atribución 4.0 Internacional
Descripción: © The Authors 2023. This manuscript version is made available under the CC-BY 4.0 license http://creativecommons.org/licenses/by/4.0/ This document is the Published version of a Published Work that appeared in final form in Frontiers in Immunology. To access the final edited and published work see https://doi.org/10.3389/fimmu.2023.1297249
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