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Título: | Changes in Calprotectin (S100A8-A9) and Aldolase in the Saliva of Horses with Equine Gastric Ulcer Syndrome |
Fecha de defensa / creación: | 16-ene-2023 |
Editorial: | MDPI |
Cita bibliográfica: | Animals 2023, 13, 1367 |
ISSN: | Electronic: 2076-2615 |
Palabras clave: | Saliva EGUS ESGD EGGD Calprotectin Aldolase Biomarkers |
Resumen: | Equine gastric ulcer syndrome (EGUS) is a highly prevalent disease that affects horses worldwide. Within EGUS, two different forms have been described: equine squamous gastric disease (ESGD) and equine glandular gastric disease (EGGD). The associated clinical signs cause detrimental activity performance, reducing the quality of life of animals. Saliva can contain biomarkers for EGUS that could be potentially used as a complementary tool for diagnosis. The objective of this work was to evaluate the measurements of calprotectin (CALP) and aldolase in the saliva of horses as potential biomarkers of EGUS. For this purpose, automated assays for the quantification of these two proteins were analytically validated and applied for detecting EGUS in a total of 131 horses divided into 5 groups: healthy horses, ESGD, EGGD, combined ESGD and EGGD, and horses with other intestinal pathologies. The assays showed good precision and accuracy in analytical validation, and they were able to discriminate between horses with EGUS and healthy horses, especially in the case of CALP, although they did not show significant differences between horses with EGUS and horses with other diseases. In conclusion, salivary CALP and aldolase can be determined in the saliva of horses and further studies are warranted to elucidate the potential of these analytes as biomarkers in EGUS. |
Autor/es principal/es: | Muñoz-Prieto, Alberto Contreras-Aguilar, María Dolores Cerón, José Joaquín Ayala de la Peña, Ignacio Martín-Cuervo, María David Eckersall, Peter Holm Henriksen, Ida-Marie Tecles, Fernando Hansen, Sanni |
Facultad/Departamentos/Servicios: | Facultades, Departamentos, Servicios y Escuelas::Departamentos de la UMU::Medicina y Cirugía Animal |
Versión del editor: | https://www.mdpi.com/2076-2615/13/8/1367 |
URI: | http://hdl.handle.net/10201/143807 |
DOI: | https://doi.org/10.3390/ani13081367 |
Tipo de documento: | info:eu-repo/semantics/article |
Número páginas / Extensión: | 10 |
Derechos: | info:eu-repo/semantics/openAccess Atribución 4.0 Internacional |
Descripción: | © 2023. The authors. This document is made available under the CC-BY 4.0 license http://creativecommons.org/licenses/by /4.0/ This document is the published version of a published work that appeared in final form in Animals To access the final work, see DOI: https://www.mdpi.com/2076-2615/13/8/1367 |
Aparece en las colecciones: | Artículos: Medicina y Cirugía Animal |
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Fichero | Descripción | Tamaño | Formato | |
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Artic DEF aldolasa cab ulc gastr 2023 Animals.pdf | 687,29 kB | Adobe PDF | Visualizar/Abrir |
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