Por favor, use este identificador para citar o enlazar este ítem:
10.3389/fcvm.2022.887664
![](/digitum/image/email_logo.png)
![](/digitum/image/logo-facebook.png)
Registro completo de metadatos
Campo DC | Valor | Lengua/Idioma |
---|---|---|
dc.contributor.author | de la Morena Barrio, María Eugenia | - |
dc.contributor.author | Corral, Javier | - |
dc.contributor.author | López García, Cecilia | - |
dc.contributor.author | Jiménez Díaz, Víctor Alonso | - |
dc.contributor.author | Miñano, Antonia | - |
dc.contributor.author | Salvadores, Pablo Juan | - |
dc.contributor.author | Esteve Pastor, María Asunción | - |
dc.contributor.author | Baz Alonso, José Antonio | - |
dc.contributor.author | Rubio, Ana María | - |
dc.contributor.author | Sarabia Tirado, Francisco | - |
dc.contributor.author | García Navarro, Miguel | - |
dc.contributor.author | García Lara, Juan | - |
dc.contributor.author | Marín, Francisco | - |
dc.contributor.author | Vicente, Vicente | - |
dc.contributor.author | Pinar, Eduardo | - |
dc.contributor.author | Cánovas López, Sergio | - |
dc.contributor.author | de la Morena, Gonzalo | - |
dc.date.accessioned | 2024-07-18T08:36:57Z | - |
dc.date.available | 2024-07-18T08:36:57Z | - |
dc.date.issued | 2022-07-22 | - |
dc.identifier.citation | Frontiers in Cardiovascular Medicine, vol. 9, 887664. | es |
dc.identifier.issn | 2297-055X | - |
dc.identifier.uri | http://hdl.handle.net/10201/143186 | - |
dc.description.abstract | Background: Aortic valve replacement is the gold standard treatment for severe symptomatic aortic stenosis, but thrombosis of bioprosthetic valves (PVT) remains a concern. Objective: To analyze the factors involved in the contact pathway during aortic valve replacement and to assess their impact on the development of thromboembolic complications. Methods: The study was conducted in 232 consecutive patients who underwent: transcatheter aortic valve replacement (TAVR, N = 155), and surgical valve replacement (SAVR, N = 77) (MUVITAVI project). Demographic and clinical data, outcomes including a combined end point (CEP) of thrombotic events, and imaging controls were recruited. Samples were collected 24 h before and 48 h after valve replacement. FXII, FXI and (pre)kallikrein were evaluated by Western Blot and specific ELISA with nanobodies. Results: The CEP of thrombotic events was reached by 19 patients: 13 patients presented systemic embolic events and 6 patients subclinical PVT. Valve replacement did not cause FXII activation or generation of kallikrein. There was a significant reduction of FXI levels associated with the procedure, which was statistically more pronounced in SAVR than in TAVR. Cases with reductions of FXI below 80% of basal values had a lower incidence of embolic events during the procedure than patients in whom FXI increased above 150%: 2.7 vs. 16.7%; p: 0.04. Conclusion: TAVR or SAVR did not significantly activate the contact pathway. A significant reduction of FXI, was observed, particularly in SAVR, associated with lower incidence of thrombotic events. These results encourage evaluating the usefulness and safety of FXI-directed antithrombotic treatments in these patients. | es |
dc.format | application/pdf | es |
dc.format.extent | 12 | es |
dc.language | eng | es |
dc.relation | Sin financiación externa a la Universidad | es |
dc.rights | info:eu-repo/semantics/openAccess | es |
dc.rights | Attribution-NonCommercial-NoDerivatives 4.0 Internacional | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | * |
dc.subject | contact pathway | es |
dc.subject | aortic valve replacement | es |
dc.subject | thrombosis | es |
dc.subject | factor XI | es |
dc.subject | factor XII | es |
dc.title | Contact pathway in surgical and transcatheter aortic valve replacement | es |
dc.type | info:eu-repo/semantics/article | es |
dc.identifier.doi | 10.3389/fcvm.2022.887664 | - |
Aparece en las colecciones: | Artículos: Cirugía, Pediatría y Obstetricia y Ginecología |
Ficheros en este ítem:
Fichero | Descripción | Tamaño | Formato | |
---|---|---|---|---|
fcvm-09-887664.pdf | 5,22 MB | Adobe PDF | Visualizar/Abrir |
Este ítem está sujeto a una licencia Creative Commons Licencia Creative Commons