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10.1096/fj.202201965RR
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Campo DC | Valor | Lengua/Idioma |
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dc.contributor.author | López Gálvez, Raquel | - |
dc.contributor.author | Rivera Caravaca, José Miguel | - |
dc.contributor.author | Mandaglio Collados, Darío | - |
dc.contributor.author | Orenes Piñero, Esteban | - |
dc.contributor.author | Lahoz, Álvaro | - |
dc.contributor.author | Hernández Romero, Diana | - |
dc.contributor.author | M. Martínez, Carlos | - |
dc.contributor.author | Carpes, Marina | - |
dc.contributor.author | Arribas, José María | - |
dc.contributor.author | Cánovas López, Sergio | - |
dc.contributor.author | Y. H. Lip, Gregory | - |
dc.contributor.author | Marín, Francisco | - |
dc.date.accessioned | 2024-07-18T08:35:25Z | - |
dc.date.available | 2024-07-18T08:35:25Z | - |
dc.date.issued | 2023-04-28 | - |
dc.identifier.citation | The FASEB Journal. Volume 37, Issue 6 e22941 | es |
dc.identifier.issn | 0892-6638 | - |
dc.identifier.issn | 1530-6860 | - |
dc.identifier.uri | http://hdl.handle.net/10201/143185 | - |
dc.description.abstract | Obstructive sleep apnea (OSA) promotes atrial remodeling and fibrosis, providing a substrate for atrial fibrillation (AF). Herein, we investigate the pathophysiological mechanisms of AF in association with OSA in a cohort of cardiac surgery patients. A prospective study including patients undergoing cardiac surgery. Biomarkers reflective of AF pathophysiology (interleukin [IL-6], C-reactive protein [CRP], von Willebrand factor [vWF], N-terminal pro-brain natriuretic peptide [NT-proBNP], high-sensitivity Troponin T [hs-TnT], and Galectin-3 [Gal-3]) was assessed by functional or immunological assays. miRNAs involved in AF were analyzed by reverse transcription-polymerase chain reaction (RT-PCR). Using atrial tissue samples, fibrosis was assessed by Masson's trichrome. Connexin 40 and 43 (Cx40; Cx43) were evaluated by immunolabeling. Fifty-six patients (15 with OSA and 41 non-OSA) were included in this hypothesis-generating pilot study. OSA group had a higher incidence of postoperative AF (POAF) (46.7% vs. 19.5%; p = .042), presented an increased risk of POAF (OR 3.61, 95% CI 1.01–12.92), and had significantly higher baseline levels of NT-proBNP (p = .044), vWF (p = .049), Gal-3 (p = .009), IL-6 (p = .002), and CRP (p = .003). This group presented lower levels of miR-21 and miR-208 (both p < .05). Also, lower Cx40 levels in POAF and/or OSA patients (50.0% vs. 81.8%, p = .033) were found. The presence of interstitial fibrosis (according to myocardial collagen by Masson's trichrome) was raised in OSA patients (86.7% vs. 53.7%, p = .024). Several biomarkers and miRNAs involved in inflammation and fibrosis were dysregulated in OSA patients, which together with a higher degree of interstitial fibrosis, altered miRNA, and Cxs expression predisposes to the development of a substrate that increases the AF risk. | es |
dc.format | application/pdf | es |
dc.format.extent | 11 | es |
dc.language | eng | es |
dc.relation | Sin financiación externa a la Universidad | es |
dc.rights | info:eu-repo/semantics/openAccess | es |
dc.rights | Attribution-NonCommercial-NoDerivatives 4.0 Internacional | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | * |
dc.subject | atrial fibrillation | es |
dc.subject | connexins | es |
dc.subject | fibrosis | es |
dc.subject | miRNA | es |
dc.subject | obstructive sleep apnea | es |
dc.title | Molecular mechanisms of postoperative atrial fibrillation in patients with obstructive sleep apnea | es |
dc.type | info:eu-repo/semantics/article | es |
dc.identifier.doi | 10.1096/fj.202201965RR | - |
Aparece en las colecciones: | Artículos: Cirugía, Pediatría y Obstetricia y Ginecología |
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