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10.1093/icvts/ivad115
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Título: | Durability of bioprosthetic aortic valve replacement in patients under the age of 60 years — 1-year follow-up from the prospective INDURE registry |
Fecha de publicación: | 18-jul-2023 |
Cita bibliográfica: | Interdisciplinary CardioVascular and Thoracic Surgery, Volume 37, Issue 4, October 2023, ivad115. |
ISSN: | 2753-670X |
Palabras clave: | Surgical aortic valve replacement Structural valve degeneration Valve durability |
Resumen: | OBJECTIVES We report 1-year safety and clinical outcomes in patients <60 years undergoing bioprosthetic surgical aortic valve intervention. METHODS The INSPIRIS RESILIA Durability Registry is a prospective, multicentre registry to assess clinical outcomes of patients <60 years. Patients with planned SAVR with or without concomitant replacement of the ascending aorta and/or coronary bypass surgery were included. Time-related valve safety, haemodynamic performance and quality of life (QoL) at 1 year were assessed. RESULTS A total of 421 patients were documented with a mean age of 53.5 years, 76.5% being male and 27.2% in NYHA class III/IV. Outcomes within 30 days included cardiovascular-related mortality (0.7%), time-related valve safety (VARC-2; 5.8%), thromboembolic events (1.7%), valve-related life-threatening bleeding (VARC-2; 4.3%) and permanent pacemaker implantation (3.8%). QoL was significantly increased at 6 months and sustained at 1 year. Freedom from all-cause mortality at 1 year was 98.3% (95% confidence interval 97.1; 99.6) and 81.8% were NYHA I versus 21.9% at baseline. No patient developed structural valve deterioration stage 3 (VARC-3). The mean aortic pressure gradient was 12.6 mmHg at 1 year and the effective orifice area was 1.9 cm2. CONCLUSIONS The 1-year data from the INSPIRIS RESILIA valve demonstrate good safety and excellent haemodynamic performance as well as an early QoL improvement. |
Autor/es principal/es: | Meuris, Bart Roussel, Jean-Christian Borger, Michael A Siepe, Matthias Stefano, Pierluigi Laufer, Günther Langanay, Thierry Theron, Alexis Grabenwöger, Martin Binder, Konrad Demers, Philippe Pesotto, Renzo van Leeuwen, Wouter Bourguignon, Thierry Cánovas López, Sergio Mariscalco, Giovanni Coscioni, Enrico Dagenais, Francois Wendler, Olaf Polvani, Gianluca Eden, Matthias Botta, Beate Bramlage, Peter de Paulis, Ruggero |
URI: | http://hdl.handle.net/10201/143183 |
DOI: | 10.1093/icvts/ivad115 |
Tipo de documento: | info:eu-repo/semantics/article |
Número páginas / Extensión: | 11 |
Derechos: | info:eu-repo/semantics/openAccess Attribution-NonCommercial-NoDerivatives 4.0 Internacional |
Aparece en las colecciones: | Artículos: Cirugía, Pediatría y Obstetricia y Ginecología |
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